Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta) (eIF3 p66)
1_MAKFM 6_ TPVIQ 11_ DNPSG 16_ WGPCA 21_ VPEQF 26_ RDMPY 31_ QPFSK 36_ GDRLG 41_ KVADW 46_ TGATY 51_ QDKRY 56_ TNKYS 61_ SQFGG 66_ GSQYA 71_ YFHEE 76_ DESSF 81_ QLVDT 86_ ARTQK 91_ TAYQR 96_ NRMRF 101_ AQRNL 106_ RRDKD 111_ RRNML 116_ QFNLQ 121_ ILPKS 126_ AKQKE 131_ RERIR 136_ LQKKF 141_ QKQFG 146_ VRQKW 151_ DQKSQ 156_ KPRDS 161_ SVEVR 166_ SDWEV 171_ KEEMD 176_ FPQLM 181_ KMRYL 186_ EVSEP 191_ QDIEC 196_ CGALE 201_ YYDKA 206_ FDRIT 211_ TRSEK 216_ PLRSI 221_ KRIFH 226_ TVTTT 231_ DDPVI 236_ RKLAK 241_ TQGNV 246_ FATDA 251_ ILATL 256_ MSCTR 261_ SVYSW 266_ DIVVQ 271_ RVGSK 276_ LFFDK 281_ RDNSD 286_ FDLLT 291_ VSETA 296_ NEPPQ 301_ DEGNS 306_ FNSPR 311_ NLAME 316_ ATYIN 321_ HNFSQ 326_ QCLRM 331_ GKERY 336_ NFPNP 341_ NPFVE 346_ DDMDK 351_ NEIAS 356_ VAYRY 361_ RRWKL 366_ GDDID 371_ LIVRC 376_ EHDGV 381_ MTGAN 386_ GEVSF 391_ INIKT 396_ LNEWD 401_ SRHCN 406_ GVDWR 411_ QKLDS 416_ QRGAV 421_ IATEL 426_ KNNSY 431_ KLARW 436_ TCCAL 441_ LAGSE 446_ YLKLG 451_ YVSRY 456_ HVKDS 461_ SRHVI 466_ LGTQQ 471_ FKPNE 476_ FASQI 481_ NLSVE 486_ NAWGI 491_ LRCVI 496_ DICMK 501_ LEEGK 506_ YLILK 511_ DPNKQ 516_ VIRVY 521_ SLPDG 526_ TFSSD 531_ EDEEE 536_ EEEEE 541_EEEEE
1: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815)
2: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426)