Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit)
1_MASRK 6_ EGTGS 11_ TATSS 16_ SSTAG 21_ AAGKG 26_ KGKGG 31_ SGDSA 36_ VKQVQ 41_ IDGLV 46_ VLKII 51_ KHYQE 56_ EGQGT 61_ EVVQG 66_ VLLGL 71_ VVEDR 76_ LEITN 81_ CFPFP 86_ QHTED 91_ DADFD 96_ EVQYQ 101_ MEMMR 106_ SLRHV 111_ NIDHL 116_ HVGWY 121_ QSTYY 126_ GSFVT 131_ RALLD 136_ SQFSY 141_ QHAIE 146_ ESVVL 151_ IYDPI 156_ KTAQG 161_ SLSLK 166_ AYRLT 171_ PKLME 176_ VCKEK 181_ DFSPE 186_ ALKKA 191_ NITFE 196_ YMFEE 201_ VPIVI 206_ KNSHL 211_ INVLM 216_ WELEK 221_ KSAVA 226_ DKHEL 231_ LSLAS 236_ SNHLG 241_ KNLQL 246_ LMDRV 251_ DEMSQ 256_ DIVKY 261_ NTYMR 266_ NTSKQ 271_ QQQKH 276_ QYQQR 281_ RQQEN 286_ MQRQS 291_ RGEPP 296_ LPEED 301_ LSKLF 306_ KPPQP 311_ PARMD 316_ SLLIA 321_ GQINT 326_ YCQNI 331_ KEFTA 336_ QNLGK 341_ LFMAQ 346_ALQEY
1: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)