Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8)
1_MDLNR 6_ IIQAL 11_ KGTID 16_ PKLRI 21_ AAENE 26_ LNQSY 31_ KIINF 36_ APSLL 41_ RIIVS 46_ DHVEF 51_ PVRQA 56_ AAIYL 61_ KNMVT 66_ QYWPD 71_ REPPP 76_ GEAIF 81_ PFNIH 86_ ENDRQ 91_ QIRDN 96_ IVEGI 101_ IRSPD 106_ LVRVQ 111_ LTMCL 116_ RAIIK 121_ HDFPG 126_ HWPGV 131_ VDKID 136_ YYLQS 141_ QSSAS 146_ WLGSL 151_ LCLYQ 156_ LVKTY 161_ EYKKA 166_ EEREP 171_ LIIAM 176_ QIFLP 181_ RIQQQ 186_ IVQLL 191_ PDSSY 196_ YSVLL 201_ QKQIL 206_ KIFYA 211_ LVQYA 216_ LPLQL 221_ VNNQT 226_ MTTWM 231_ EIFRT 236_ IIDRT 241_ VPPET 246_ LHIDE 251_ DDRPE 256_ LVWWK 261_ CKKWA 266_ LHIVA 271_ RLFER 276_ YGSPG 281_ NVTKE 286_ YFEFS 291_ EFFLK 296_ TYAVG 301_ IQQVL 306_ LKILD 311_ QYRQK 316_ EYVAP 321_ RVLQQ 326_ AFNYL 331_ NQGVV 336_ HSITW 341_ KQMKP 346_ HIQNI 351_ SEDVI 356_ FSVMC 361_ YKDED 366_ EELWQ 371_ EDPYE 376_ YIRMK 381_ FDIFE 386_ DYASP 391_ TTAAQ 396_ TLLYT 401_ AAKKR 406_ KEVLP 411_ KMMAF 416_ CYQIL 421_ TDPNF 426_ DPRKK 431_ DGALH 436_ VIGSL 441_ AEILL 446_ KKSLF 451_ KDQME 456_ LFLQN 461_ HVFPL 466_ LLSNL 471_ GYLRA 476_ RSCWV 481_ LHAFS 486_ SLKFH 491_ NELNL 496_ RNAVE 501_ LAKKS 506_ LIEDK 511_ EMPVK 516_ VEAAL 521_ ALQSL 526_ ISNQI 531_ QAKEY 536_ MKPHV 541_ RPIMQ 546_ ELLHI 551_ VRETE 556_ NDDVT 561_ NVIQK 566_ MICEY 571_ SQEVA 576_ SIAVD 581_ MTQHL 586_ AEIFG 591_ KVLQS 596_ DEYEE 601_ VEDKT 606_ VMAMG 611_ ILHTI 616_ DTILT 621_ VVEDH 626_ KEITQ 631_ QLENI 636_ CLRII 641_ DLVLQ 646_ KHVIE 651_ FYEEI 656_ LSLAY 661_ SLTCH 666_ SISPQ 671_ MWQLL 676_ GILYE 681_ VFQQD 686_ CFEYF 691_ TDMMP 696_ LLHNY 701_ VTIDT 706_ DTLLS 711_ NAKHL 716_ EILFT 721_ MCRKV 726_ LCGDA 731_ GEDAE 736_ CHAAK 741_ LLEVI 746_ ILQCK 751_ GRGID 756_ QCIPL 761_ FVQLV 766_ LERLT 771_ RGVKT 776_ SELRT 781_ MCLQV 786_ AIAAL 791_ YYNPD 796_ LLLHT 801_ LERIQ 806_ LPHNP 811_ GPITV 816_ QFINQ 821_ WMNDT 826_ DCFLG 831_ HHDRK 836_ MCIIG 841_ LSILL 846_ ELQNR 851_ PPAVD 856_ AVVGQ 861_ IVPSI 866_ LFLFL 871_ GLKQV 876_ CATRQ 881_ LVNRE 886_ DRSKA 891_ EKADM 896_ EENEE 901_ ISSDE 906_ EETNV 911_ TAQAM 916_ QSNNG 921_ RGEDE 926_ EEEDD 931_ DWDEE 936_ VLEET 941_ ALEGF 946_ STPLD 951_ LDNSV 956_ DEYQF 961_ FTQAL 966_ ITVQS 971_ RDAAW 976_ YQLLM 981_ APLSE 986_ DQRTA 991_ LQEVY 996_ TLAEH 1001_ RRTVA 1006_ EAKKK 1011_ IEQQG 1016_ GFTFE 1021_ NKGVL 1026_ SAFNF 1031_GTVPS
1: Involved in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, may serve as receptor for nuclear localization signals (NLS) and promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:9214382). In vitro mediates the nuclear import of the signal recognition particle protein SRP19 (PubMed:11682607). May also be involved in cytoplasm-to-nucleus shuttling of a broad spectrum of other cargos, including Argonaute-microRNAs complexes, the JUN protein, RELA/NF-kappa-B p65 subunit, the translation initiation factor EIF4E and a set of receptor-activated mothers against decapentaplegic homolog (SMAD) transcription factors that play a critical role downstream of the large family of transforming growth factor beta and bone morphogenetic protein (BMP) cytokines (Probable)