Glutamate receptor ionotropic, NMDA 2D (GluN2D) (EB11) (Glutamate [NMDA] receptor subunit epsilon-4) (N-methyl D-aspartate receptor subtype 2D) (NMDAR2D) (NR2D)
1_MRGAG 6_ GPRGP 11_ RGPAK 16_ MLLLL 21_ ALACA 26_ SPFPE 31_ EAPGP 36_ GGAGG 41_ PGGGL 46_ GGARP 51_ LNVAL 56_ VFSGP 61_ AYAAE 66_ AARLG 71_ PAVAA 76_ AVRSP 81_ GLDVR 86_ PVALV 91_ LNGSD 96_ PRSLV 101_ LQLCD 106_ LLSGL 111_ RVHGV 116_ VFEDD 121_ SRAPA 126_ VAPIL 131_ DFLSA 136_ QTSLP 141_ IVAVH 146_ GGAAL 151_ VLTPK 156_ EKGST 161_ FLQLG 166_ SSTEQ 171_ QLQVI 176_ FEVLE 181_ EYDWT 186_ SFVAV 191_ TTRAP 196_ GHRAF 201_ LSYIE 206_ VLTDG 211_ SLVGW 216_ EHRGA 221_ LTLDP 226_ GAGEA 231_ VLSAQ 236_ LRSVS 241_ AQIRL 246_ LFCAR 251_ EEAEP 256_ VFRAA 261_ EEAGL 266_ TGSGY 271_ VWFMV 276_ GPQLA 281_ GGGGS 286_ GAPGE 291_ PPLLP 296_ GGAPL 301_ PAGLF 306_ AVRSA 311_ GWRDD 316_ LARRV 321_ AAGVA 326_ VVARG 331_ AQALL 336_ RDYGF 341_ LPELG 346_ HDCRA 351_ QNRTH 356_ RGESL 361_ HRYFM 366_ NITWD 371_ NRDYS 376_ FNEDG 381_ FLVNP 386_ SLVVI 391_ SLTRD 396_ RTWEV 401_ VGSWE 406_ QQTLR 411_ LKYPL 416_ WSRYG 421_ RFLQP 426_ VDDTQ 431_ HLTVA 436_ TLEER 441_ PFVIV 446_ EPADP 451_ ISGTC 456_ IRDSV 461_ PCRSQ 466_ LNRTH 471_ SPPPD 476_ APRPE 481_ KRCCK 486_ GFCID 491_ ILKRL 496_ AHTIG 501_ FSYDL 506_ YLVTN 511_ GKHGK 516_ KIDGV 521_ WNGMI 526_ GEVFY 531_ QRADM 536_ AIGSL 541_ TINEE 546_ RSEIV 551_ DFSVP 556_ FVETG 561_ ISVMV 566_ ARSNG 571_ TVSPS 576_ AFLEP 581_ YSPAV 586_ WVMMF 591_ VMCLT 596_ VVAVT 601_ VFIFE 606_ YLSPV 611_ GYNRS 616_ LATGK 621_ RPGGS 626_ TFTIG 631_ KSIWL 636_ LWALV 641_ FNNSV 646_ PVENP 651_ RGTTS 656_ KIMVL 661_ VWAFF 666_ AVIFL 671_ ASYTA 676_ NLAAF 681_ MIQEE 686_ YVDTV 691_ SGLSD 696_ RKFQR 701_ PQEQY 706_ PPLKF 711_ GTVPN 716_ GSTEK 721_ NIRSN 726_ YPDMH 731_ SYMVR 736_ YNQPR 741_ VEEAL 746_ TQLKA 751_ GKLDA 756_ FIYDA 761_ AVLNY 766_ MARKD 771_ EGCKL 776_ VTIGS 781_ GKVFA 786_ TTGYG 791_ IALHK 796_ GSRWK 801_ RPIDL 806_ ALLQF 811_ LGDDE 816_ IEMLE 821_ RLWLS 826_ GICHN 831_ DKIEV 836_ MSSKL 841_ DIDNM 846_ AGVFY 851_ MLLVA 856_ MGLSL 861_ LVFAW 866_ EHLVY 871_ WRLRH 876_ CLGPT 881_ HRMDF 886_ LLAFS 891_ RGMYS 896_ CCSAE 901_ AAPPP 906_ AKPPP 911_ PPQPL 916_ PSPAY 921_ PAPRP 926_ APGPA 931_ PFVPR 936_ ERASV 941_ DRWRR 946_ TKGAG 951_ PPGGA 956_ GLADG 961_ FHRYY 966_ GPIEP 971_ QGLGL 976_ GLGEA 981_ RAAPR 986_ GAAGR 991_ PLSPP 996_ AAQPP 1001_ QKPPP 1006_ SYFAI 1011_ VRDKE 1016_ PAEPP 1021_ AGAFP 1026_ GFPSP 1031_ PAPPA 1036_ AAATA 1041_ VGPPL 1046_ CRLAF 1051_ EDESP 1056_ PAPAR 1061_ WPRSD 1066_ PESQP 1071_ LLGPG 1076_ AGGAG 1081_ GTGGA 1086_ GGGAP 1091_ AAPPP 1096_ CRAAP 1101_ PPCPY 1106_ LDLEP 1111_ SPSDS 1116_ EDSES 1121_ LGGAS 1126_ LGGLE 1131_ PWWFA 1136_ DFPYP 1141_ YAERL 1146_ GPPPG 1151_ RYWSV 1156_ DKLGG 1161_ WRAGS 1166_ WDYLP 1171_ PRSGP 1176_ AAWHC 1181_ RHCAS 1186_ LELLP 1191_ PPRHL 1196_ SCSHD 1201_ GLDGG 1206_ WWAPP 1211_ PPPWA 1216_ AGPLP 1221_ RRRAR 1226_ CGCPR 1231_ SHPHR 1236_ PRASH 1241_ RTPAA 1246_ AAPHH 1251_ HRHRR 1256_ AAGGW 1261_ DLPPP 1266_ APTSR 1271_ SLEDL 1276_ SSCPR 1281_ AAPAR 1286_ RLTGP 1291_ SRHAR 1296_ RCPHA 1301_ AHWGP 1306_ PLPTA 1311_ SHRRH 1316_ RGGDL 1321_ GTRRG 1326_ SAHFS 1331_SLESE
1: Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:26875626, PubMed:27616483, PubMed:28126851, PubMed:9489750). Participates in synaptic plasticity for learning and memory formation (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626, PubMed:27616483, PubMed:28126851, PubMed:9489750). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:28095420, PubMed:28126851, PubMed:9489750)