Probable low affinity copper uptake protein 2 (Copper transporter 2) (hCTR2) (Solute carrier family 31 member 2)
1_MAMHF 6_ IFSDT 11_ AVLLF 16_ DFWSV 21_ HSPAG 26_ MALSV 31_ LVLLL 36_ LAVLY 41_ EGIKV 46_ GKAKL 51_ LNQVL 56_ VNLPT 61_ SISQQ 66_ TIAET 71_ DGDSA 76_ GSDSF 81_ PVGRT 86_ HHRWY 91_ LCHFG 96_ QSLIH 101_ VIQVV 106_ IGYFI 111_ MLAVM 116_ SYNTW 121_ IFLGV 126_ VLGSA 131_ VGYYL 136_AYPLL
1: Does not function as a copper(1+) importer in vivo (By similarity). However, in vitro functions as a low-affinity copper(1+) importer (PubMed:17617060, PubMed:17944601). Regulator of SLC31A1 which facilitates the cleavage of the SLC31A1 ecto-domain or which stabilizes the truncated form of SLC31A1 (Truncated CTR1 form), thereby drives the SLC31A1 truncated form-dependent endosomal copper export and modulates the copper and cisplatin accumulation via SLC31A1 (By similarity)