ATP-binding cassette sub-family C member 3 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multispecific organic anion transporter 2) (Multi-specific organic anion transporter D) (MOAT-D) (Multidrug resistance-associated protein 3)
1_MDALC 6_ GSGEL 11_ GSKFW 16_ DSNLS 21_ VHTEN 26_ PDLTP 31_ CFQNS 36_ LLAWV 41_ PCIYL 46_ WVALP 51_ CYLLY 56_ LRHHC 61_ RGYII 66_ LSHLS 71_ KLKMV 76_ LGVLL 81_ WCVSW 86_ ADLFY 91_ SFHGL 96_ VHGRA 101_ PAPVF 106_ FVTPL 111_ VVGVT 116_ MLLAT 121_ LLIQY 126_ ERLQG 131_ VQSSG 136_ VLIIF 141_ WFLCV 146_ VCAIV 151_ PFRSK 156_ ILLAK 161_ AEGEI 166_ SDPFR 171_ FTTFY 176_ IHFAL 181_ VLSAL 186_ ILACF 191_ REKPP 196_ FFSAK 201_ NVDPN 206_ PYPET 211_ SAGFL 216_ SRLFF 221_ WWFTK 226_ MAIYG 231_ YRHPL 236_ EEKDL 241_ WSLKE 246_ EDRSQ 251_ MVVQQ 256_ LLEAW 261_ RKQEK 266_ QTARH 271_ KASAA 276_ PGKNA 281_ SGEDE 286_ VLLGA 291_ RPRPR 296_ KPSFL 301_ KALLA 306_ TFGSS 311_ FLISA 316_ CFKLI 321_ QDLLS 326_ FINPQ 331_ LLSIL 336_ IRFIS 341_ NPMAP 346_ SWWGF 351_ LVAGL 356_ MFLCS 361_ MMQSL 366_ ILQHY 371_ YHYIF 376_ VTGVK 381_ FRTGI 386_ MGVIY 391_ RKALV 396_ ITNSV 401_ KRAST 406_ VGEIV 411_ NLMSV 416_ DAQRF 421_ MDLAP 426_ FLNLL 431_ WSAPL 436_ QIILA 441_ IYFLW 446_ QNLGP 451_ SVLAG 456_ VAFMV 461_ LLIPL 466_ NGAVA 471_ VKMRA 476_ FQVKQ 481_ MKLKD 486_ SRIKL 491_ MSEIL 496_ NGIKV 501_ LKLYA 506_ WEPSF 511_ LKQVE 516_ GIRQG 521_ ELQLL 526_ RTAAY 531_ LHTTT 536_ TFTWM 541_ CSPFL 546_ VTLIT 551_ LWVYV 556_ YVDPN 561_ NVLDA 566_ EKAFV 571_ SVSLF 576_ NILRL 581_ PLNML 586_ PQLIS 591_ NLTQA 596_ SVSLK 601_ RIQQF 606_ LSQEE 611_ LDPQS 616_ VERKT 621_ ISPGY 626_ AITIH 631_ SGTFT 636_ WAQDL 641_ PPTLH 646_ SLDIQ 651_ VPKGA 656_ LVAVV 661_ GPVGC 666_ GKSSL 671_ VSALL 676_ GEMEK 681_ LEGKV 686_ HMKGS 691_ VAYVP 696_ QQAWI 701_ QNCTL 706_ QENVL 711_ FGKAL 716_ NPKRY 721_ QQTLE 726_ ACALL 731_ ADLEM 736_ LPGGD 741_ QTEIG 746_ EKGIN 751_ LSGGQ 756_ RQRVS 761_ LARAV 766_ YSDAD 771_ IFLLD 776_ DPLSA 781_ VDSHV 786_ AKHIF 791_ DHVIG 796_ PEGVL 801_ AGKTR 806_ VLVTH 811_ GISFL 816_ PQTDF 821_ IIVLA 826_ DGQVS 831_ EMGPY 836_ PALLQ 841_ RNGSF 846_ ANFLC 851_ NYAPD 856_ EDQGH 861_ LEDSW 866_ TALEG 871_ AEDKE 876_ ALLIE 881_ DTLSN 886_ HTDLT 891_ DNDPV 896_ TYVVQ 901_ KQFMR 906_ QLSAL 911_ SSDGE 916_ GQGRP 921_ VPRRH 926_ LGPSE 931_ KVQVT 936_ EAKAD 941_ GALTQ 946_ EEKAA 951_ IGTVE 956_ LSVFW 961_ DYAKA 966_ VGLCT 971_ TLAIC 976_ LLYVG 981_ QSAAA 986_ IGANV 991_ WLSAW 996_ TNDAM 1001_ ADSRQ 1006_ NNTSL 1011_ RLGVY 1016_ AALGI 1021_ LQGFL 1026_ VMLAA 1031_ MAMAA 1036_ GGIQA 1041_ ARVLH 1046_ QALLH 1051_ NKIRS 1056_ PQSFF 1061_ DTTPS 1066_ GRILN 1071_ CFSKD 1076_ IYVVD 1081_ EVLAP 1086_ VILML 1091_ LNSFF 1096_ NAIST 1101_ LVVIM 1106_ ASTPL 1111_ FTVVI 1116_ LPLAV 1121_ LYTLV 1126_ QRFYA 1131_ ATSRQ 1136_ LKRLE 1141_ SVSRS 1146_ PIYSH 1151_ FSETV 1156_ TGASV 1161_ IRAYN 1166_ RSRDF 1171_ EIISD 1176_ TKVDA 1181_ NQRSC 1186_ YPYII 1191_ SNRWL 1196_ SIGVE 1201_ FVGNC 1206_ VVLFA 1211_ ALFAV 1216_ IGRSS 1221_ LNPGL 1226_ VGLSV 1231_ SYSLQ 1236_ VTFAL 1241_ NWMIR 1246_ MMSDL 1251_ ESNIV 1256_ AVERV 1261_ KEYSK 1266_ TETEA 1271_ PWVVE 1276_ GSRPP 1281_ EGWPP 1286_ RGEVE 1291_ FRNYS 1296_ VRYRP 1301_ GLDLV 1306_ LRDLS 1311_ LHVHG 1316_ GEKVG 1321_ IVGRT 1326_ GAGKS 1331_ SMTLC 1336_ LFRIL 1341_ EAAKG 1346_ EIRID 1351_ GLNVA 1356_ DIGLH 1361_ DLRSQ 1366_ LTIIP 1371_ QDPIL 1376_ FSGTL 1381_ RMNLD 1386_ PFGSY 1391_ SEEDI 1396_ WWALE 1401_ LSHLH 1406_ TFVSS 1411_ QPAGL 1416_ DFQCS 1421_ EGGEN 1426_ LSVGQ 1431_ RQLVC 1436_ LARAL 1441_ LRKSR 1446_ ILVLD 1451_ EATAA 1456_ IDLET 1461_ DNLIQ 1466_ ATIRT 1471_ QFDTC 1476_ TVLTI 1481_ AHRLN 1486_ TIMDY 1491_ TRVLV 1496_ LDKGV 1501_ VAEFD 1506_ SPANL 1511_ IAARG 1516_ IFYGM 1521_ARDAG
1: ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:10359813, PubMed:11581266, PubMed:15083066). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:11581266, PubMed:15083066). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:10359813, PubMed:11581266)