ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4)
1_MLPVY 6_ QEVKP 11_ NPLQD 16_ ANLCS 21_ RVFFW 26_ WLNPL 31_ FKIGH 36_ KRRLE 41_ EDDMY 46_ SVLPE 51_ DRSQH 56_ LGEEL 61_ QGFWD 66_ KEVLR 71_ AENDA 76_ QKPSL 81_ TRAII 86_ KCYWK 91_ SYLVL 96_ GIFTL 101_ IEESA 106_ KVIQP 111_ IFLGK 116_ IINYF 121_ ENYDP 126_ MDSVA 131_ LNTAY 136_ AYATV 141_ LTFCT 146_ LILAI 151_ LHHLY 156_ FYHVQ 161_ CAGMR 166_ LRVAM 171_ CHMIY 176_ RKALR 181_ LSNMA 186_ MGKTT 191_ TGQIV 196_ NLLSN 201_ DVNKF 206_ DQVTV 211_ FLHFL 216_ WAGPL 221_ QAIAV 226_ TALLW 231_ MEIGI 236_ SCLAG 241_ MAVLI 246_ ILLPL 251_ QSCFG 256_ KLFSS 261_ LRSKT 266_ ATFTD 271_ ARIRT 276_ MNEVI 281_ TGIRI 286_ IKMYA 291_ WEKSF 296_ SNLIT 301_ NLRKK 306_ EISKI 311_ LRSSC 316_ LRGMN 321_ LASFF 326_ SASKI 331_ IVFVT 336_ FTTYV 341_ LLGSV 346_ ITASR 351_ VFVAV 356_ TLYGA 361_ VRLTV 366_ TLFFP 371_ SAIER 376_ VSEAI 381_ VSIRR 386_ IQTFL 391_ LLDEI 396_ SQRNR 401_ QLPSD 406_ GKKMV 411_ HVQDF 416_ TAFWD 421_ KASET 426_ PTLQG 431_ LSFTV 436_ RPGEL 441_ LAVVG 446_ PVGAG 451_ KSSLL 456_ SAVLG 461_ ELAPS 466_ HGLVS 471_ VHGRI 476_ AYVSQ 481_ QPWVF 486_ SGTLR 491_ SNILF 496_ GKKYE 501_ KERYE 506_ KVIKA 511_ CALKK 516_ DLQLL 521_ EDGDL 526_ TVIGD 531_ RGTTL 536_ SGGQK 541_ ARVNL 546_ ARAVY 551_ QDADI 556_ YLLDD 561_ PLSAV 566_ DAEVS 571_ RHLFE 576_ LCICQ 581_ ILHEK 586_ ITILV 591_ THQLQ 596_ YLKAA 601_ SQILI 606_ LKDGK 611_ MVQKG 616_ TYTEF 621_ LKSGI 626_ DFGSL 631_ LKKDN 636_ EESEQ 641_ PPVPG 646_ TPTLR 651_ NRTFS 656_ ESSVW 661_ SQQSS 666_ RPSLK 671_ DGALE 676_ SQDTE 681_ NVPVT 686_ LSEEN 691_ RSEGK 696_ VGFQA 701_ YKNYF 706_ RAGAH 711_ WIVFI 716_ FLILL 721_ NTAAQ 726_ VAYVL 731_ QDWWL 736_ SYWAN 741_ KQSML 746_ NVTVN 751_ GGGNV 756_ TEKLD 761_ LNWYL 766_ GIYSG 771_ LTVAT 776_ VLFGI 781_ ARSLL 786_ VFYVL 791_ VNSSQ 796_ TLHNK 801_ MFESI 806_ LKAPV 811_ LFFDR 816_ NPIGR 821_ ILNRF 826_ SKDIG 831_ HLDDL 836_ LPLTF 841_ LDFIQ 846_ TLLQV 851_ VGVVS 856_ VAVAV 861_ IPWIA 866_ IPLVP 871_ LGIIF 876_ IFLRR 881_ YFLET 886_ SRDVK 891_ RLEST 896_ TRSPV 901_ FSHLS 906_ SSLQG 911_ LWTIR 916_ AYKAE 921_ ERCQE 926_ LFDAH 931_ QDLHS 936_ EAWFL 941_ FLTTS 946_ RWFAV 951_ RLDAI 956_ CAMFV 961_ IIVAF 966_ GSLIL 971_ AKTLD 976_ AGQVG 981_ LALSY 986_ ALTLM 991_ GMFQW 996_ CVRQS 1001_ AEVEN 1006_ MMISV 1011_ ERVIE 1016_ YTDLE 1021_ KEAPW 1026_ EYQKR 1031_ PPPAW 1036_ PHEGV 1041_ IIFDN 1046_ VNFMY 1051_ SPGGP 1056_ LVLKH 1061_ LTALI 1066_ KSQEK 1071_ VGIVG 1076_ RTGAG 1081_ KSSLI 1086_ SALFR 1091_ LSEPE 1096_ GKIWI 1101_ DKILT 1106_ TEIGL 1111_ HDLRK 1116_ KMSII 1121_ PQEPV 1126_ LFTGT 1131_ MRKNL 1136_ DPFNE 1141_ HTDEE 1146_ LWNAL 1151_ QEVQL 1156_ KETIE 1161_ DLPGK 1166_ MDTEL 1171_ AESGS 1176_ NFSVG 1181_ QRQLV 1186_ CLARA 1191_ ILRKN 1196_ QILII 1201_ DEATA 1206_ NVDPR 1211_ TDELI 1216_ QKKIR 1221_ EKFAH 1226_ CTVLT 1231_ IAHRL 1236_ NTIID 1241_ SDKIM 1246_ VLDSG 1251_ RLKEY 1256_ DEPYV 1261_ LLQNK 1266_ ESLFY 1271_ KMVQQ 1276_ LGKAE 1281_ AAALT 1286_ ETAKQ 1291_ VYFKR 1296_ NYPHI 1301_ GHTDH 1306_ MVTNT 1311_ SNGQP 1316_STLTI
1: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685)