C-C motif chemokine 25 (Chemokine TECK) (Small-inducible cytokine A25) (Thymus-expressed chemokine)
1_MNLWL 6_ LACLV 11_ AGFLG 16_ AWAPA 21_ VHTQG 26_ VFEDC 31_ CLAYH 36_ YPIGW 41_ AVLRR 46_ AWTYR 51_ IQEVS 56_ GSCNL 61_ PAAIF 66_ YLPKR 71_ HRKVC 76_ GNPKS 81_ REVQR 86_ AMKLL 91_ DARNK 96_ VFAKL 101_ HHNTQ 106_ TFQAG 111_ PHAVK 116_ KLSSG 121_ NSKLS 126_ SSKFS 131_ NPISS 136_ SKRNV 141_SLLIS
1: Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4