Toll-like receptor 3 (CD antigen CD283)
1_MRQTL 6_ PCIYF 11_ WGGLL 16_ PFGML 21_ CASST 26_ TKCTV 31_ SHEVA 36_ DCSHL 41_ KLTQV 46_ PDDLP 51_ TNITV 56_ LNLTH 61_ NQLRR 66_ LPAAN 71_ FTRYS 76_ QLTSL 81_ DVGFN 86_ TISKL 91_ EPELC 96_ QKLPM 101_ LKVLN 106_ LQHNE 111_ LSQLS 116_ DKTFA 121_ FCTNL 126_ TELHL 131_ MSNSI 136_ QKIKN 141_ NPFVK 146_ QKNLI 151_ TLDLS 156_ HNGLS 161_ STKLG 166_ TQVQL 171_ ENLQE 176_ LLLSN 181_ NKIQA 186_ LKSEE 191_ LDIFA 196_ NSSLK 201_ KLELS 206_ SNQIK 211_ EFSPG 216_ CFHAI 221_ GRLFG 226_ LFLNN 231_ VQLGP 236_ SLTEK 241_ LCLEL 246_ ANTSI 251_ RNLSL 256_ SNSQL 261_ STTSN 266_ TTFLG 271_ LKWTN 276_ LTMLD 281_ LSYNN 286_ LNVVG 291_ NDSFA 296_ WLPQL 301_ EYFFL 306_ EYNNI 311_ QHLFS 316_ HSLHG 321_ LFNVR 326_ YLNLK 331_ RSFTK 336_ QSISL 341_ ASLPK 346_ IDDFS 351_ FQWLK 356_ CLEHL 361_ NMEDN 366_ DIPGI 371_ KSNMF 376_ TGLIN 381_ LKYLS 386_ LSNSF 391_ TSLRT 396_ LTNET 401_ FVSLA 406_ HSPLH 411_ ILNLT 416_ KNKIS 421_ KIESD 426_ AFSWL 431_ GHLEV 436_ LDLGL 441_ NEIGQ 446_ ELTGQ 451_ EWRGL 456_ ENIFE 461_ IYLSY 466_ NKYLQ 471_ LTRNS 476_ FALVP 481_ SLQRL 486_ MLRRV 491_ ALKNV 496_ DSSPS 501_ PFQPL 506_ RNLTI 511_ LDLSN 516_ NNIAN 521_ INDDM 526_ LEGLE 531_ KLEIL 536_ DLQHN 541_ NLARL 546_ WKHAN 551_ PGGPI 556_ YFLKG 561_ LSHLH 566_ ILNLE 571_ SNGFD 576_ EIPVE 581_ VFKDL 586_ FELKI 591_ IDLGL 596_ NNLNT 601_ LPASV 606_ FNNQV 611_ SLKSL 616_ NLQKN 621_ LITSV 626_ EKKVF 631_ GPAFR 636_ NLTEL 641_ DMRFN 646_ PFDCT 651_ CESIA 656_ WFVNW 661_ INETH 666_ TNIPE 671_ LSSHY 676_ LCNTP 681_ PHYHG 686_ FPVRL 691_ FDTSS 696_ CKDSA 701_ PFELF 706_ FMINT 711_ SILLI 716_ FIFIV 721_ LLIHF 726_ EGWRI 731_ SFYWN 736_ VSVHR 741_ VLGFK 746_ EIDRQ 751_ TEQFE 756_ YAAYI 761_ IHAYK 766_ DKDWV 771_ WEHFS 776_ SMEKE 781_ DQSLK 786_ FCLEE 791_ RDFEA 796_ GVFEL 801_ EAIVN 806_ SIKRS 811_ RKIIF 816_ VITHH 821_ LLKDP 826_ LCKRF 831_ KVHHA 836_ VQQAI 841_ EQNLD 846_ SIILV 851_ FLEEI 856_ PDYKL 861_ NHALC 866_ LRRGM 871_ FKSHC 876_ ILNWP 881_ VQKER 886_ IGAFR 891_ HKLQV 896_ALGSK
1: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response