C-C motif chemokine 16 (Chemokine CC-4) (HCC-4) (Chemokine LEC) (IL-10-inducible chemokine) (LCC-1) (Liver-expressed chemokine) (Lymphocyte and monocyte chemoattractant) (LMC) (Monotactin-1) (MTN-1) (NCC-4) (Small-inducible cytokine A16)
1_MKVSE 6_ AALSL 11_ LVLIL 16_ IITSA 21_ SRSQP 26_ KVPEW 31_ VNTPS 36_ TCCLK 41_ YYEKV 46_ LPRRL 51_ VVGYR 56_ KALNC 61_ HLPAI 66_ IFVTK 71_ RNREV 76_ CTNPN 81_ DDWVQ 86_ EYIKD 91_ PNLPL 96_ LPTRN 101_ LSTVK 106_ IITAK 111_NGQPQ
1: Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES