Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC)
1_MSKNT 6_ VSSAR 11_ FRKVD 16_ VDEYD 21_ ENKFV 26_ DEEDG 31_ GDGQA 36_ GPDEG 41_ EVDSC 46_ LRQGN 51_ MTAAL 56_ QAALK 61_ NPPIN 66_ TKSQA 71_ VKDRA 76_ GSIVL 81_ KVLIS 86_ FKAND 91_ IEKAV 96_ QSLDK 101_ NGVDL 106_ LMKYI 111_ YKGFE 116_ SPSDN 121_ SSAML 126_ LQWHE 131_ KALAA 136_ GGVGS 141_ IVRVL 146_TARKT
1: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947)