CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
1_MSAEV 6_ IHQVE 11_ EALDT 16_ DEKEM 21_ LLFLC 26_ RDVAI 31_ DVVPP 36_ NVRDL 41_ LDILR 46_ ERGKL 51_ SVGDL 56_ AELLY 61_ RVRRF 66_ DLLKR 71_ ILKMD 76_ RKAVE 81_ THLLR 86_ NPHLV 91_ SDYRV 96_ LMAEI 101_ GEDLD 106_ KSDVS 111_ SLIFL 116_ MKDYM 121_ GRGKI 126_ SKEKS 131_ FLDLV 136_ VELEK 141_ LNLVA 146_ PDQLD 151_ LLEKC 156_ LKNIH 161_ RIDLK 166_ TKIQK 171_ YKQSV 176_ QGAGT 181_ SYRNV 186_ LQAAI 191_ QKSLK 196_ DPSNN 201_ FRLHN 206_ GRSKE 211_ QRLKE 216_ QLGAQ 221_ QEPVK 226_ KSIQE 231_ SEAFL 236_ PQSIP 241_ EERYK 246_ MKSKP 251_ LGICL 256_ IIDCI 261_ GNETE 266_ LLRDT 271_ FTSLG 276_ YEVQK 281_ FLHLS 286_ MHGIS 291_ QILGQ 296_ FACMP 301_ EHRDY 306_ DSFVC 311_ VLVSR 316_ GGSQS 321_ VYGVD 326_ QTHSG 331_ LPLHH 336_ IRRMF 341_ MGDSC 346_ PYLAG 351_ KPKMF 356_ FIQNY 361_ VVSEG 366_ QLEDS 371_ SLLEV 376_ DGPAM 381_ KNVEF 386_ KAQKR 391_ GLCTV 396_ HREAD 401_ FFWSL 406_ CTADM 411_ SLLEQ 416_ SHSSP 421_ SLYLQ 426_ CLSQK 431_ LRQER 436_ KRPLL 441_ DLHIE 446_ LNGYM 451_ YDWNS 456_ RVSAK 461_ EKYYV 466_ WLQHT 471_LRKKL
1: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity