Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
1_MVAHN 6_ QVAAD 11_ NAVST 16_ AAEPR 21_ RRPEP 26_ SSSSS 31_ SSPAA 36_ PARPR 41_ PCPAV 46_ PAPAP 51_ GDTHF 56_ RTFRS 61_ HADYR 66_ RITRA 71_ SALLD 76_ ACGFY 81_ WGPLS 86_ VHGAH 91_ ERLRA 96_ EPVGT 101_ FLVRD 106_ SRQRN 111_ CFFAL 116_ SVKMA 121_ SGPTS 126_ IRVHF 131_ QAGRF 136_ HLDGS 141_ RESFD 146_ CLFEL 151_ LEHYV 156_ AAPRR 161_ MLGAP 166_ LRQRR 171_ VRPLQ 176_ ELCRQ 181_ RIVAT 186_ VGREN 191_ LARIP 196_ LNPVL 201_ RDYLS 206_SFPFQ
1: Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed:32499645, PubMed:33087723). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity (PubMed:9341160). Regulates IFN-gamma (IFNG)-mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11278610, PubMed:11313480)