Transcription factor MafG (V-maf musculoaponeurotic fibrosarcoma oncogene homolog G) (hMAF)
1_MTTPN 6_ KGNKA 11_ LKVKR 16_ EPGEN 21_ GTSLT 26_ DEELV 31_ TMSVR 36_ ELNQH 41_ LRGLS 46_ KEEIV 51_ QLKQR 56_ RRTLK 61_ NRGYA 66_ ASCRV 71_ KRVTQ 76_ KEELE 81_ KQKAE 86_ LQQEV 91_ EKLAS 96_ ENASM 101_ KLELD 106_ ALRSK 111_ YEALQ 116_ TFART 121_ VARSP 126_ VAPAR 131_ GPLAA 136_ GLGPL 141_ VPGKV 146_ AATSV 151_ ITIVK 156_SKTDA
1: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:11154691, PubMed:8932385, PubMed:9421508). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691). Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PubMed:11154691). Activates globin gene expression when associated with NFE2L2 (PubMed:11154691). May be involved in signal transduction of extracellular H(+) (By similarity)