E3 ubiquitin-protein ligase RNF113A (EC 2.3.2.27) (Cwc24 homolog) (RING finger protein 113A) (Zinc finger protein 183)
1_MAEQL 6_ SPGKA 11_ VDQVC 16_ TFLFK 21_ KPGRK 26_ GAAGR 31_ RKRPA 36_ CDPEP 41_ GESGS 46_ SSDEG 51_ CTVVR 56_ PEKKR 61_ VTHNP 66_ MIQKT 71_ RDSGK 76_ QKAAY 81_ GDLSS 86_ EEEEE 91_ NEPES 96_ LGVVY 101_ KSTRS 106_ AKPVG 111_ PEDMG 116_ ATAVY 121_ ELDTE 126_ KERDA 131_ QAIFE 136_ RSQKI 141_ QEELR 146_ GKEDD 151_ KIYRG 156_ INNYQ 161_ KYMKP 166_ KDTSM 171_ GNASS 176_ GMVRK 181_ GPIRA 186_ PEHLR 191_ ATVRW 196_ DYQPD 201_ ICKDY 206_ KETGF 211_ CGFGD 216_ SCKFL 221_ HDRSD 226_ YKHGW 231_ QIERE 236_ LDEGR 241_ YGVYE 246_ DENYE 251_ VGSDD 256_ EEIPF 261_ KCFIC 266_ RQSFQ 271_ NPVVT 276_ KCRHY 281_ FCESC 286_ ALQHF 291_ RTTPR 296_ CYVCD 301_ QQTNG 306_ VFNPA 311_ KELIA 316_ KLEKH 321_ RATGE 326_ GGASD 331_ LPEDP 336_DEDAI
1: Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106, PubMed:29361316). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins (PubMed:28978524, PubMed:29144457). Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents (PubMed:29144457). Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling (PubMed:28978524)