P2X purinoceptor 6 (P2X6) (ATP receptor) (P2XM) (Purinergic receptor) (Purinergic receptor P2X-like 1)
1_MCPQL 6_ AGAGS 11_ MGSPG 16_ ATTGW 21_ GLLDY 26_ KTEKY 31_ VMTRN 36_ WRVGA 41_ LQRLL 46_ QFGIV 51_ VYVVG 56_ WALLA 61_ KKGYQ 66_ ERDLE 71_ PQFSI 76_ ITKLK 81_ GVSVT 86_ QIKEL 91_ GNRLW 96_ DVADF 101_ VKPPQ 106_ GENVF 111_ FLVTN 116_ FLVTP 121_ AQVQG 126_ RCPEH 131_ PSVPL 136_ ANCWV 141_ DEDCP 146_ EGEGG 151_ THSHG 156_ VKTGQ 161_ CVVFN 166_ GTHRT 171_ CEIWS 176_ WCPVE 181_ SGVVP 186_ SRPLL 191_ AQAQN 196_ FTLFI 201_ KNTVT 206_ FSKFN 211_ FSKSN 216_ ALETW 221_ DPTYF 226_ KHCRY 231_ EPQFS 236_ PYCPV 241_ FRIGD 246_ LVAKA 251_ GGTFE 256_ DLALL 261_ GGSVG 266_ IRVHW 271_ DCDLD 276_ TGDSG 281_ CWPHY 286_ SFQLQ 291_ EKSYN 296_ FRTAT 301_ HWWEQ 306_ PGVEA 311_ RTLLK 316_ LYGIR 321_ FDILV 326_ TGQAG 331_ KFGLI 336_ PTAVT 341_ LGTGA 346_ AWLGV 351_ VTFFC 356_ DLLLL 361_ YVDRE 366_ AHFYW 371_ RTKYE 376_ EAKAP 381_ KATAN 386_ SVWRE 391_ LALAS 396_ QARLA 401_ ECLRR 406_ SSAPA 411_ PTATA 416_ AGSQT 421_ QTPGW 426_ PCPSS 431_ DTHLP 436_THSGS
1: May act as a modulatory subunit rather than a functional channel. Unlike other P2XRs members, P2RX6 does not seem to form functional homotrimers (PubMed:22378790). P2RX6 requires the presence of P2RX4 or P2RX2 to shuttle it to the plasma membrane where it may form functional heterotrimeric receptors at the plasma membrane (PubMed:22378790). P2RX6 can be translocated to the nucleus and functions as a nuclear regulator of post-transcriptional modifications in neurons (By similarity)