Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A)
1_MKSCG 6_ VSLAT 11_ AAAAA 16_ AAFGD 21_ EEKKM 26_ AAGKA 31_ SGESE 36_ EASPS 41_ LTAEE 46_ REALG 51_ GLDSR 56_ LFGFV 61_ RFHED 66_ GARTK 71_ ALLGK 76_ AVRCY 81_ ESLIL 86_ KAEGK 91_ VESDF 96_ FCQLG 101_ HFNLL 106_ LEDYP 111_ KALSA 116_ YQRYY 121_ SLQSD 126_ YWKNA 131_ AFLYG 136_ LGLVY 141_ FHYNA 146_ FQWAI 151_ KAFQE 156_ VLYVD 161_ PSFCR 166_ AKEIH 171_ LRLGL 176_ MFKVN 181_ TDYES 186_ SLKHF 191_ QLALV 196_ DCNPC 201_ TLSNA 206_ EIQFH 211_ IAHLY 216_ ETQRK 221_ YHSAK 226_ EAYEQ 231_ LLQTE 236_ NLSAQ 241_ VKATV 246_ LQQLG 251_ WMHHT 256_ VDLLG 261_ DKATK 266_ ESYAI 271_ QYLQK 276_ SLEAD 281_ PNSGQ 286_ SWYFL 291_ GRCYS 296_ SIGKV 301_ QDAFI 306_ SYRQS 311_ IDKSE 316_ ASADT 321_ WCSIG 326_ VLYQQ 331_ QNQPM 336_ DALQA 341_ YICAV 346_ QLDHG 351_ HAAAW 356_ MDLGT 361_ LYESC 366_ NQPQD 371_ AIKCY 376_ LNATR 381_ SKSCS 386_ NTSAL 391_ AARIK 396_ YLQAQ 401_ LCNLP 406_ QGSLQ 411_ NKTKL 416_ LPSIE 421_ EAWSL 426_ PIPAE 431_ LTSRQ 436_ GAMNT 441_ AQQNT 446_ SDNWS 451_ GGHAV 456_ SHPPV 461_ QQQAH 466_ SWCLT 471_ PQKLQ 476_ HLEQL 481_ RANRN 486_ NLNPA 491_ QKLML 496_ EQLES 501_ QFVLM 506_ QQHQM 511_ RPTGV 516_ AQVRS 521_ TGIPN 526_ GPTAD 531_ SSLPT 536_ NSVSG 541_ QQPQL 546_ ALTRV 551_ PSVSQ 556_ PGVRP 561_ ACPGQ 566_ PLANG 571_ PFSAG 576_ HVPCS 581_ TSRTL 586_ GSTDT 591_ ILIGN 596_ NHITG 601_ SGSNG 606_ NVPYL 611_ QRNAL 616_ TLPHN 621_ RTNLT 626_ SSAEE 631_ PWKNQ 636_ LSNST 641_ QGLHK 646_ GQSSH 651_ SAGPN 656_ GERPL 661_ SSTGP 666_ SQHLQ 671_ AAGSG 676_ IQNQN 681_ GHPTL 686_ PSNSV 691_ TQGAA 696_ LNHLS 701_ SHTAT 706_ SGGQQ 711_ GITLT 716_ KESKP 721_ SGNIL 726_ TVPET 731_ SRHTG 736_ ETPNS 741_ TASVE 746_ GLPNH 751_ VHQMT 756_ ADAVC 761_ SPSHG 766_ DSKSP 771_ GLLSS 776_ DNPQL 781_ SALLM 786_ GKANN 791_ NVGTG 796_ TCDKV 801_ NNIHP 806_ AVHTK 811_ TDNSV 816_ ASSPS 821_ SAIST 826_ ATPSP 831_ KSTEQ 836_ TTTNS 841_ VTSLN 846_ SPHSG 851_ LHTIN 856_ GEGME 861_ ESQSP 866_ MKTDL 871_ LLVNH 876_ KPSPQ 881_ IIPSM 886_ SVSIY 891_ PSSAE 896_ VLKAC 901_ RNLGK 906_ NGLSN 911_ SSILL 916_ DKCPP 921_ PRPPS 926_ SPYPP 931_ LPKDK 936_ LNPPT 941_ PSIYL 946_ ENKRD 951_ AFFPP 956_ LHQFC 961_ TNPNN 966_ PVTVI 971_ RGLAG 976_ ALKLD 981_ LGLFS 986_ TKTLV 991_ EANNE 996_ HMVEV 1001_ RTQLL 1006_ QPADE 1011_ NWDPT 1016_ GTKKI 1021_ WHCES 1026_ NRSHT 1031_ TIAKY 1036_ AQYQA 1041_ SSFQE 1046_ SLREE 1051_ NEKRS 1056_ HHKDH 1061_ SDSES 1066_ TSSDN 1071_ SGRRR 1076_ KGPFK 1081_ TIKFG 1086_ TNIDL 1091_ SDDKK 1096_ WKLQL 1101_ HELTK 1106_ LPAFV 1111_ RVVSA 1116_ GNLLS 1121_ HVGHT 1126_ ILGMN 1131_ TVQLY 1136_ MKVPG 1141_ SRTPG 1146_ HQENN 1151_ NFCSV 1156_ NINIG 1161_ PGDCE 1166_ WFVVP 1171_ EGYWG 1176_ VLNDF 1181_ CEKNN 1186_ LNFLM 1191_ GSWWP 1196_ NLEDL 1201_ YEANV 1206_ PVYRF 1211_ IQRPG 1216_ DLVWI 1221_ NAGTV 1226_ HWVQA 1231_ IGWCN 1236_ NIAWN 1241_ VGPLT 1246_ ACQYK 1251_ LAVER 1256_ YEWNK 1261_ LQSVK 1266_ SIVPM 1271_ VHLSW 1276_ NMARN 1281_ IKVSD 1286_ PKLFE 1291_ MIKYC 1296_ LLRTL 1301_ KQCQT 1306_ LREAL 1311_ IAAGK 1316_ EIIWH 1321_ GRTKE 1326_ EPAHY 1331_ CSICE 1336_ VEVFD 1341_ LLFVT 1346_ NESNS 1351_ RKTYI 1356_ VHCQD 1361_ CARKT 1366_ SGNLE 1371_ NFVVL 1376_ EQYKM 1381_ EDLMQ 1386_ VYDQF 1391_ TLAPP 1396_LPSAS
1: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17761849, PubMed:17851529). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17713478, PubMed:17761849, PubMed:17851529). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity)