Pyrin (Marenostrin)
1_MAKTP 6_ SDHLL 11_ STLEE 16_ LVPYD 21_ FEKFK 26_ FKLQN 31_ TSVQK 36_ EHSRI 41_ PRSQI 46_ QRARP 51_ VKMAT 56_ LLVTY 61_ YGEEY 66_ AVQLT 71_ LQVLR 76_ AINQR 81_ LLAEE 86_ LHRAA 91_ IQEYS 96_ TQENG 101_ TDDSA 106_ ASSSL 111_ GENKP 116_ RSLKT 121_ PDHPE 126_ GNEGN 131_ GPRPY 136_ GGGAA 141_ SLRCS 146_ QPEAG 151_ RGLSR 156_ KPLSK 161_ RREKA 166_ SEGLD 171_ AQGKP 176_ RTRSP 181_ ALPGG 186_ RSPGP 191_ CRALE 196_ GGQAE 201_ VRLRR 206_ NASSA 211_ GRLQG 216_ LAGGA 221_ PGQKE 226_ CRPFE 231_ VYLPS 236_ GKMRP 241_ RSLEV 246_ TISTG 251_ EKAPA 256_ NPEIL 261_ LTLEE 266_ KTAAN 271_ LDSAT 276_ EPRAR 281_ PTPDG 286_ GASAD 291_ LKEGP 296_ GNPEH 301_ SVTGR 306_ PPDTA 311_ ASPRC 316_ HAQEG 321_ DPVDG 326_ TCVRD 331_ SCSFP 336_ EAVSG 341_ HPQAS 346_ GSRSP 351_ GCPRC 356_ QDSHE 361_ RKSPG 366_ SLSPQ 371_ PLPQC 376_ KRHLK 381_ QVQLL 386_ FCEDH 391_ DEPIC 396_ LICSL 401_ SQEHQ 406_ GHRVR 411_ PIEEV 416_ ALEHK 421_ KKIQK 426_ QLEHL 431_ KKLRK 436_ SGEEQ 441_ RSYGE 446_ EKAVS 451_ FLKQT 456_ EALKQ 461_ RVQRK 466_ LEQVY 471_ YFLEQ 476_ QEHFF 481_ VASLE 486_ DVGQM 491_ VGQIR 496_ KAYDT 501_ RVSQD 506_ IALLD 511_ ALIGE 516_ LEAKE 521_ CQSEW 526_ ELLQD 531_ IGDIL 536_ HRAKT 541_ VPVPE 546_ KWTTP 551_ QEIKQ 556_ KIQLL 561_ HQKSE 566_ FVEKS 571_ TKYFS 576_ ETLRS 581_ EMEMF 586_ NVPEL 591_ IGAQA 596_ HAVNV 601_ ILDAE 606_ TAYPN 611_ LIFSD 616_ DLKSV 621_ RLGNK 626_ WERLP 631_ DGPQR 636_ FDSCI 641_ IVLGS 646_ PSFLS 651_ GRRYW 656_ EVEVG 661_ DKTAW 666_ ILGAC 671_ KTSIS 676_ RKGNM 681_ TLSPE 686_ NGYWV 691_ VIMMK 696_ ENEYQ 701_ ASSVP 706_ PTRLL 711_ IKEPP 716_ KRVGI 721_ FVDYR 726_ VGSIS 731_ FYNVT 736_ ARSHI 741_ YTFAS 746_ CSFSG 751_ PLQPI 756_ FSPGT 761_ RDGGK 766_ NTAPL 771_ TICPV 776_GGQGP
1: Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma (PubMed:10807793, PubMed:11468188, PubMed:16037825, PubMed:16785446, PubMed:17431422, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923, PubMed:26347139, PubMed:27030597, PubMed:28835462). Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy (PubMed:16785446, PubMed:17431422, PubMed:26347139). Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (PubMed:16037825, PubMed:27030597, PubMed:28835462). Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (By similarity). It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923). Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923)