ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15) (Splicing factor Prp43) (hPrp43)
1_MSKRH 6_ RLDLG 11_ EDYPS 16_ GKKRA 21_ GTDGK 26_ DRDRD 31_ RDRED 36_ RSKDR 41_ DRERD 46_ RGDRE 51_ REREK 56_ EKEKE 61_ LRAST 66_ NAMLI 71_ SAGLP 76_ PLKAS 81_ HSAHS 86_ THSAH 91_ STHST 96_ HSAHS 101_ THAGH 106_ AGHTS 111_ LPQCI 116_ NPFTN 121_ LPHTP 126_ RYYDI 131_ LKKRL 136_ QLPVW 141_ EYKDR 146_ FTDIL 151_ VRHQS 156_ FVLVG 161_ ETGSG 166_ KTTQI 171_ PQWCV 176_ EYMRS 181_ LPGPK 186_ RGVAC 191_ TQPRR 196_ VAAMS 201_ VAQRV 206_ ADEMD 211_ VMLGQ 216_ EVGYS 221_ IRFED 226_ CSSAK 231_ TILKY 236_ MTDGM 241_ LLREA 246_ MNDPL 251_ LERYG 256_ VIILD 261_ EAHER 266_ TLATD 271_ ILMGV 276_ LKEVV 281_ RQRSD 286_ LKVIV 291_ MSATL 296_ DAGKF 301_ QIYFD 306_ NCPLL 311_ TIPGR 316_ THPVE 321_ IFYTP 326_ EPERD 331_ YLEAA 336_ IRTVI 341_ QIHMC 346_ EEEEG 351_ DLLLF 356_ LTGQE 361_ EIDEA 366_ CKRIK 371_ REVDD 376_ LGPEV 381_ GDIKI 386_ IPLYS 391_ TLPPQ 396_ QQQRI 401_ FEPPP 406_ PKKQN 411_ GAIGR 416_ KVVVS 421_ TNIAE 426_ TSLTI 431_ DGVVF 436_ VIDPG 441_ FAKQK 446_ VYNPR 451_ IRVES 456_ LLVTA 461_ ISKAS 466_ AQQRA 471_ GRAGR 476_ TRPGK 481_ CFRLY 486_ TEKAY 491_ KTEMQ 496_ DNTYP 501_ EILRS 506_ NLGSV 511_ VLQLK 516_ KLGID 521_ DLVHF 526_ DFMDP 531_ PAPET 536_ LMRAL 541_ ELLNY 546_ LAALN 551_ DDGDL 556_ TELGS 561_ MMAEF 566_ PLDPQ 571_ LAKMV 576_ IASCD 581_ YNCSN 586_ EVLSI 591_ TAMLS 596_ VPQCF 601_ VRPTE 606_ AKKAA 611_ DEAKM 616_ RFAHI 621_ DGDHL 626_ TLLNV 631_ YHAFK 636_ QNHES 641_ VQWCY 646_ DNFIN 651_ YRSLM 656_ SADNV 661_ RQQLS 666_ RIMDR 671_ FNLPR 676_ RSTDF 681_ TSRDY 686_ YINIR 691_ KALVT 696_ GYFMQ 701_ VAHLE 706_ RTGHY 711_ LTVKD 716_ NQVVQ 721_ LHPST 726_ VLDHK 731_ PEWVL 736_ YNEFV 741_ LTTKN 746_ YIRTC 751_ TDIKP 756_ EWLVK 761_ IAPQY 766_ YDMSN 771_ FPQCE 776_ AKRQL 781_ DRIIA 786_KLQSK
1: RNA helicase involved in mRNA processing and antiviral innate immunity (PubMed:19103666, PubMed:19432882, PubMed:24782566, PubMed:24990078, PubMed:32179686, PubMed:34161762). Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA (PubMed:19103666). In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns (PubMed:19103666). Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome (PubMed:24782566, PubMed:24990078, PubMed:34161762). Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3) (PubMed:24782566, PubMed:24990078, PubMed:34161762). Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses (PubMed:34161762). The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu (PubMed:34161762). Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells (By similarity)