Small G protein signaling modulator 2 (RUN and TBC1 domain-containing protein 1)
1_MGSAE 6_ DAVKE 11_ KLLWN 16_ VKKEV 21_ KQIME 26_ EAVTR 31_ KFVHE 36_ DSSHI 41_ IALCG 46_ AVEAC 51_ LLHQL 56_ RRRAA 61_ GFLRS 66_ DKMAA 71_ LFTKV 76_ GKTCP 81_ VAGEI 86_ CHKVQ 91_ ELQQQ 96_ AEGRK 101_ PSGVS 106_ QEALR 111_ RQGSA 116_ SGKAP 121_ ALSPQ 126_ ALKHV 131_ WVRTA 136_ LIEKV 141_ LDKVV 146_ QYLAE 151_ NCSKY 156_ YEKEA 161_ LLADP 166_ VFGPI 171_ LASLL 176_ VGPCA 181_ LEYTK 186_ LKTAD 191_ HYWTD 196_ PSADE 201_ LVQRH 206_ RIRGP 211_ PTRQD 216_ SPAKR 221_ PALGI 226_ RKRHS 231_ SGSAS 236_ EDRLA 241_ ACARE 246_ CVESL 251_ HQNSR 256_ TRLLY 261_ GKNHV 266_ LVQPK 271_ EDMEA 276_ VPGYL 281_ SLHQS 286_ AESLT 291_ LKWTP 296_ NQLMN 301_ GTLGD 306_ SELEK 311_ SVYWD 316_ YALVV 321_ PFSQV 326_ VCIHC 331_ HQQKS 336_ GGTLV 341_ LVSQD 346_ GIQRP 351_ PLHFP 356_ QGGHL 361_ LSFLS 366_ CLENG 371_ LLPRG 376_ QLEPP 381_ LWTQQ 386_ GKGKV 391_ FPKLR 396_ KRSSI 401_ RSVDM 406_ EEMGT 411_ GRATD 416_ YVFRI 421_ IYPGH 426_ RHEHN 431_ AGDMI 436_ EMQGF 441_ GPSLP 446_ AWHLE 451_ PLCSQ 456_ GSSCL 461_ SCSSS 466_ SSPHA 471_ TPSHC 476_ SCIPD 481_ RLPLR 486_ LLCES 491_ MKRQI 496_ VSRAF 501_ YGWLA 506_ HCRHL 511_ STVRT 516_ HLSAL 521_ VHHSV 526_ IPPDR 531_ PPGAS 536_ AGLTK 541_ DVWSK 546_ YQKDK 551_ KNYKE 556_ LELLR 561_ QVYYG 566_ GIEHE 571_ IRKDV 576_ WPFLL 581_ GHYKF 586_ GMSKK 591_ EMEQV 596_ DAVVA 601_ ARYQQ 606_ VLAEW 611_ KACEV 616_ VVRQR 621_ EREAH 626_ PATRT 631_ KFSSG 636_ SSIDS 641_ HVQRL 646_ IHRDS 651_ TISND 656_ VFISV 661_ DDLEP 666_ PEPQD 671_ PEDSR 676_ PKPEQ 681_ EAGPG 686_ TPGTA 691_ VVEQQ 696_ HSVEF 701_ DSPDS 706_ GLPSS 711_ RNYSV 716_ ASGIQ 721_ SSLDE 726_ GQSVG 731_ FEEED 736_ GGGEE 741_ GSSGP 746_ GPAAH 751_ TLREP 756_ QDPSQ 761_ EKPQA 766_ GELEA 771_ GEELA 776_ AVCAA 781_ AYTIE 786_ LLDTV 791_ ALNLH 796_ RIDKD 801_ VQRCD 806_ RNYWY 811_ FTPPN 816_ LERLR 821_ DVMCS 826_ YVWEH 831_ LDVGY 836_ VQGMC 841_ DLLAP 846_ LLVTL 851_ DNDQL 856_ AYSCF 861_ SHLMK 866_ RMSQN 871_ FPNGG 876_ AMDTH 881_ FANMR 886_ SLIQI 891_ LDSEL 896_ FELMH 901_ QNGDY 906_ THFYF 911_ CYRWF 916_ LLDFK 921_ RELLY 926_ EDVFA 931_ VWEVI 936_ WAARH 941_ ISSEH 946_ FVLFI 951_ ALALV 956_ EAYRE 961_ IIRDN 966_ NMDFT 971_ DIIKF 976_ FNERA 981_ EHHDA 986_ QEILR 991_ IARDL 996_ VHKVQ 1001_MLIEN
1: Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed:21808068, PubMed:26620560). Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560)