Methylcytosine dioxygenase TET3 (EC 1.14.11.n2)
1_MSQFQ 6_ VPLAV 11_ QPDLP 16_ GLYDF 21_ PQRQV 26_ MVGSF 31_ PGSGL 36_ SMAGS 41_ ESQLR 46_ GGGDG 51_ RKKRK 56_ RCGTC 61_ EPCRR 66_ LENCG 71_ ACTSC 76_ TNRRT 81_ HQICK 86_ LRKCE 91_ VLKKK 96_ VGLLK 101_ EVEIK 106_ AGEGA 111_ GPWGQ 116_ GAAVK 121_ TGSEL 126_ SPVDG 131_ PVPGQ 136_ MDSGP 141_ VYHGD 146_ SRQLS 151_ ASGVP 156_ VNGAR 161_ EPAGP 166_ SLLGT 171_ GGPWR 176_ VDQKP 181_ DWEAA 186_ PGPAH 191_ TARLE 196_ DAHDL 201_ VAFSA 206_ VAEAV 211_ SSYGA 216_ LSTRL 221_ YETFN 226_ REMSR 231_ EAGNN 236_ SRGPR 241_ PGPEG 246_ CSAGS 251_ EDLDT 256_ LQTAL 261_ ALARH 266_ GMKPP 271_ NCNCD 276_ GPECP 281_ DYLEW 286_ LEGKI 291_ KSVVM 296_ EGGEE 301_ RPRLP 306_ GPLPP 311_ GEAGL 316_ PAPST 321_ RPLLS 326_ SEVPQ 331_ ISPQE 336_ GLPLS 341_ QSALS 346_ IAKEK 351_ NISLQ 356_ TAIAI 361_ EALTQ 366_ LSSAL 371_ PQPSH 376_ STPQA 381_ SCPLP 386_ EALSP 391_ PAPFR 396_ SPQSY 401_ LRAPS 406_ WPVVP 411_ PEEHS 416_ SFAPD 421_ SSAFP 426_ PATPR 431_ TEFPE 436_ AWGTD 441_ TPPAT 446_ PRSSW 451_ PMPRP 456_ SPDPM 461_ AELEQ 466_ LLGSA 471_ SDYIQ 476_ SVFKR 481_ PEALP 486_ TKPKV 491_ KVEAP 496_ SSSPA 501_ PAPSP 506_ VLQRE 511_ APTPS 516_ SEPDT 521_ HQKAQ 526_ TALQQ 531_ HLHHK 536_ RSLFL 541_ EQVHD 546_ TSFPA 551_ PSEPS 556_ APGWW 561_ PPPSS 566_ PVPRL 571_ PDRPP 576_ KEKKK 581_ KLPTP 586_ AGGPV 591_ GTEKA 596_ APGIK 601_ PSVRK 606_ PIQIK 611_ KSRPR 616_ EAQPL 621_ FPPVR 626_ QIVLE 631_ GLRSP 636_ ASQEV 641_ QAHPP 646_ APLPA 651_ SQGSA 656_ VPLPP 661_ EPSLA 666_ LFAPS 671_ PSRDS 676_ LLPPT 681_ QEMRS 686_ PSPMT 691_ ALQPG 696_ STGPL 701_ PPADD 706_ KLEEL 711_ IRQFE 716_ AEFGD 721_ SFGLP 726_ GPPSV 731_ PIQDP 736_ ENQQT 741_ CLPAP 746_ ESPFA 751_ TRSPK 756_ QIKIE 761_ SSGAV 766_ TVLST 771_ TCFHS 776_ EEGGQ 781_ EATPT 786_ KAENP 791_ LTPTL 796_ SGFLE 801_ SPLKY 806_ LDTPT 811_ KSLLD 816_ TPAKR 821_ AQAEF 826_ PTCDC 831_ VEQIV 836_ EKDEG 841_ PYYTH 846_ LGSGP 851_ TVASI 856_ RELME 861_ ERYGE 866_ KGKAI 871_ RIEKV 876_ IYTGK 881_ EGKSS 886_ RGCPI 891_ AKWVI 896_ RRHTL 901_ EEKLL 906_ CLVRH 911_ RAGHH 916_ CQNAV 921_ IVILI 926_ LAWEG 931_ IPRSL 936_ GDTLY 941_ QELTD 946_ TLRKY 951_ GNPTS 956_ RRCGL 961_ NDDRT 966_ CACQG 971_ KDPNT 976_ CGASF 981_ SFGCS 986_ WSMYF 991_ NGCKY 996_ ARSKT 1001_ PRKFR 1006_ LAGDN 1011_ PKEEE 1016_ VLRKS 1021_ FQDLA 1026_ TEVAP 1031_ LYKRL 1036_ APQAY 1041_ QNQVT 1046_ NEEIA 1051_ IDCRL 1056_ GLKEG 1061_ RPFAG 1066_ VTACM 1071_ DFCAH 1076_ AHKDQ 1081_ HNLYN 1086_ GCTVV 1091_ CTLTK 1096_ EDNRC 1101_ VGKIP 1106_ EDEQL 1111_ HVLPL 1116_ YKMAN 1121_ TDEFG 1126_ SEENQ 1131_ NAKVG 1136_ SGAIQ 1141_ VLTAF 1146_ PREVR 1151_ RLPEP 1156_ AKSCR 1161_ QRQLE 1166_ ARKAA 1171_ AEKKK 1176_ IQKEK 1181_ LSTPE 1186_ KIKQE 1191_ ALELA 1196_ GITSD 1201_ PGLSL 1206_ KGGLS 1211_ QQGLK 1216_ PSLKV 1221_ EPQNH 1226_ FSSFK 1231_ YSGNA 1236_ VVESY 1241_ SVLGN 1246_ CRPSD 1251_ PYSMN 1256_ SVYSY 1261_ HSYYA 1266_ QPSLT 1271_ SVNGF 1276_ HSKYA 1281_ LPSFS 1286_ YYGFP 1291_ SSNPV 1296_ FPSQF 1301_ LGPGA 1306_ WGHSG 1311_ SSGSF 1316_ EKKPD 1321_ LHALH 1326_ NSLSP 1331_ AYGGA 1336_ EFAEL 1341_ PSQAV 1346_ PTDAH 1351_ HPTPH 1356_ HQQPA 1361_ YPGPK 1366_ EYLLP 1371_ KAPLL 1376_ HSVSR 1381_ DPSPF 1386_ AQSSN 1391_ CYNRS 1396_ IKQEP 1401_ VDPLT 1406_ QAEPV 1411_ PRDAG 1416_ KMGKT 1421_ PLSEV 1426_ SQNGG 1431_ PSHLW 1436_ GQYSG 1441_ GPSMS 1446_ PKRTN 1451_ GVGGS 1456_ WGVFS 1461_ SGESP 1466_ AIVPD 1471_ KLSSF 1476_ GASCL 1481_ APSHF 1486_ TDGQW 1491_ GLFPG 1496_ EGQQA 1501_ ASHSG 1506_ GRLRG 1511_ KPWSP 1516_ CKFGN 1521_ STSAL 1526_ AGPSL 1531_ TEKPW 1536_ ALGAG 1541_ DFNSA 1546_ LKGSP 1551_ GFQDK 1556_ LWNPM 1561_ KGEEG 1566_ RIPAA 1571_ GASQL 1576_ DRAWQ 1581_ SFGLP 1586_ LGSSE 1591_ KLFGA 1596_ LKSEE 1601_ KLWDP 1606_ FSLEE 1611_ GPAEE 1616_ PPSKG 1621_ AVKEE 1626_ KGGGG 1631_ AEEEE 1636_ EELWS 1641_ DSEHN 1646_ FLDEN 1651_ IGGVA 1656_ VAPAH 1661_ GSILI 1666_ ECARR 1671_ ELHAT 1676_ TPLKK 1681_ PNRCH 1686_ PTRIS 1691_ LVFYQ 1696_ HKNLN 1701_ QPNHG 1706_ LALWE 1711_ AKMKQ 1716_ LAERA 1721_ RARQE 1726_ EAARL 1731_ GLGQQ 1736_ EAKLY 1741_ GKKRK 1746_ WGGTV 1751_ VAEPQ 1756_ QKEKK 1761_ GVVPT 1766_ RQALA 1771_ VPTDS 1776_ AVTVS 1781_ SYAYT 1786_KVTGP
1: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization (PubMed:31928709). Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation (By similarity). Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes (PubMed:23217707). In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT (PubMed:23353889). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034)