TELO2-interacting protein 1 homolog (Protein SMG10)
1_MAVFD 6_ TPEEA 11_ FGVLR 16_ PVCVQ 21_ LTKTQ 26_ TVENV 31_ EHLQT 36_ RLQAV 41_ SDSAL 46_ QELQQ 51_ YILFP 56_ LRFTL 61_ KTPGP 66_ KRERL 71_ IQSVV 76_ ECLTF 81_ VLSST 86_ CVKEQ 91_ ELLQE 96_ LFSEL 101_ SACLY 106_ SPSSQ 111_ KPAAV 116_ SEELK 121_ LAVIQ 126_ GLSTL 131_ MHSAY 136_ GDIIL 141_ TFYEP 146_ SILPR 151_ LGFAV 156_ SLLLG 161_ LAEQE 166_ KSKQI 171_ KIAAL 176_ KCLQV 181_ LLLQC 186_ DCQDH 191_ PRSLD 196_ ELEQK 201_ QLGDL 206_ FASFL 211_ PGIST 216_ ALTRL 221_ ITGDF 226_ KQGHS 231_ IVVSS 236_ LKIFY 241_ KTVSF 246_ IMADE 251_ QLKRI 256_ SKVQA 261_ KPAVE 266_ HRVAE 271_ LMVYR 276_ EADWV 281_ KKTGD 286_ KLTIL 291_ IKKII 296_ ECVSV 301_ HPHWK 306_ VRLEL 311_ VELVE 316_ DLLLK 321_ CSQSL 326_ VECAG 331_ PLLKA 336_ LVGLV 341_ NDESP 346_ EIQAQ 351_ CNKVL 356_ RHFAD 361_ QKVVV 366_ GNKAL 371_ ADILS 376_ ESLHS 381_ LATSL 386_ PRLMN 391_ SQDDQ 396_ GKFST 401_ LSLLL 406_ GYLKL 411_ LGPKI 416_ NFVLN 421_ SVAHL 426_ QRLSK 431_ ALIQV 436_ LELDV 441_ ADIKI 446_ VEERR 451_ WNSDD 456_ LNASP 461_ KTSAT 466_ QPWNR 471_ IQRRY 476_ FRFFT 481_ DERIF 486_ MLLRQ 491_ VCQLL 496_ GYYGN 501_ LYLLV 506_ DHFME 511_ LYHQS 516_ VVYRK 521_ QAAMI 526_ LNELV 531_ TGAAG 536_ LEVED 541_ LHEKH 546_ IKTNP 551_ EELRE 556_ IVTSI 561_ LEEYT 566_ SQENW 571_ YLVTC 576_ LETEE 581_ MGEEL 586_ MMEHP 591_ GLQAI 596_ TSGEH 601_ TCQVT 606_ SFLAF 611_ SKPSP 616_ TICSM 621_ NSNIW 626_ QICIQ 631_ LEGIG 636_ QFAYA 641_ LGKDF 646_ CLLLM 651_ SALYP 656_ VLEKA 661_ GDQTL 666_ LISQV 671_ ATSTM 676_ MDVCR 681_ ACGYD 686_ SLQHL 691_ INQNS 696_ DYLVN 701_ GISLN 706_ LRHLA 711_ LHPHT 716_ PKVLE 721_ VMLRN 726_ SDANL 731_ LPLVA 736_ DVVQD 741_ VLATL 746_ DQFYD 751_ KRAAS 756_ FVSVL 761_ HALMA 766_ ALAQW 771_ FPDTG 776_ NLGHL 781_ QEQSL 786_ GEEGS 791_ HLNQR 796_ PAALE 801_ KSTTT 806_ AEDIE 811_ QFLLN 816_ YLKEK 821_ DVADG 826_ NVSDF 831_ DNEEE 836_ EQSVP 841_ PKVDE 846_ NDTRP 851_ DVEPP 856_ LPLQI 861_ QIAMD 866_ VMERC 871_ IHLLS 876_ DKNLQ 881_ IRLKV 886_ LDVLD 891_ LCVVV 896_ LQSHK 901_ NQLLP 906_ LAHQA 911_ WPSLV 916_ HRLTR 921_ DAPLA 926_ VLRAF 931_ KVLRT 936_ LGSKC 941_ GDFLR 946_ SRFCK 951_ DVLPK 956_ LAGSL 961_ VTQAP 966_ ISARA 971_ GPVYS 976_ HTLAF 981_ KLQLA 986_ VLQGL 991_ GPLCE 996_ RLDLG 1001_ EGDLN 1006_ KVADA 1011_ CLIYL 1016_ SVKQP 1021_ VKLQE 1026_ AARSV 1031_ FLHLM 1036_ KVDPD 1041_ STWFL 1046_ LNELY 1051_ CPVQF 1056_ TPPHP 1061_ SLHPV 1066_ QLHGA 1071_ SGQQN 1076_ PYTTN 1081_VLQLL
1: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals