Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin)
1_MFEEP 6_ EWAEA 11_ APVAA 16_ GLGPV 21_ ISRPP 26_ PAASS 31_ QNKGS 36_ KRRQL 41_ LATLR 46_ ALEAA 51_ SLSQH 56_ PPSLC 61_ ISDSE 66_ EEEEE 71_ RKKKC 76_ PKKAS 81_ FASAS 86_ AEVGK 91_ KGKKK 96_ CQKQG 101_ PPCSD 106_ SEEEV 111_ ERKKK 116_ CHKQA 121_ LVGSD 126_ SAEDE 131_ KRKRK 136_ CQKHA 141_ PINSA 146_ QHLDN 151_ VDQTG 156_ PKAWK 161_ GSTTN 166_ DPPKQ 171_ SPGST 176_ SPKPP 181_ HTLSR 186_ KQWRN 191_ RQKNK 196_ RRCKN 201_ KFQPP 206_ QVPDQ 211_ APAEA 216_ PTEKT 221_ EVSPV 226_ PRTDS 231_ HEARA 236_ GALRA 241_ RMAQR 246_ LDGAR 251_ FRYLN 256_ EQLYS 261_ GPSSA 266_ AQRLF 271_ QEDPE 276_ AFLLY 281_ HRGFQ 286_ SQVKK 291_ WPLQP 296_ VDRIA 301_ RDLRQ 306_ RPASL 311_ VVADF 316_ GCGDC 321_ RLASS 326_ IRNPV 331_ HCFDL 336_ ASLDP 341_ RVTVC 346_ DMAQV 351_ PLEDE 356_ SVDVA 361_ VFCLS 366_ LMGTN 371_ IRDFL 376_ EEANR 381_ VLKPG 386_ GLLKV 391_ AEVSS 396_ RFEDV 401_ RTFLR 406_ AVTKL 411_ GFKIV 416_ SKDLT 421_ NSHFF 426_ LFDFQ 431_ KTGPP 436_ LVGPK 441_ AQLSG 446_ LQLQP 451_CLYKR
1: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown