E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2)
1_MSQYT 6_ EKEPA 11_ AMDQE 16_ SGKAV 21_ WPKPA 26_ GGYQT 31_ ITGRR 36_ YGRRH 41_ AYVSF 46_ KPCMT 51_ RHERS 56_ LGRAG 61_ DDYEV 66_ LELDD 71_ VPKEN 76_ SSGSS 81_ PLDQV 86_ DSSLP 91_ SEPIF 96_ EKSET 101_ EIPTC 106_ GSALN 111_ QTTES 116_ SQSFV 121_ AVHHS 126_ EEGRD 131_ TLGSS 136_ TNLHN 141_ HSEGE 146_ YIPGA 151_ CSASS 156_ VQNGI 161_ ALVHT 166_ DSYDP 171_ DGKHG 176_ EDNDH 181_ LQLSA 186_ EVVEG 191_ SRYQE 196_ SLGNT 201_ VFELE 206_ NREAE 211_ AYTGL 216_ SPPVP 221_ SFNCE 226_ VRDEF 231_ EELDS 236_ VPLVK 241_ SSAGD 246_ TEFVH 251_ QNSQE 256_ IQRSS 261_ QDEMV 266_ STKQQ 271_ NNTSQ 276_ ERQTE 281_ HSPED 286_ AACGP 291_ GHICS 296_ EQNTN 301_ DREKN 306_ HGSSP 311_ EQVVR 316_ PKVRK 321_ LISSS 326_ QVDQE 331_ TGFNR 336_ HEAKQ 341_ RSVQR 346_ WREAL 351_ EVEES 356_ GSDDL 361_ LIKCE 366_ EYDGE 371_ HDCMF 376_ LDPPY 381_ SRVIT 386_ QRETE 391_ NNQMT 396_ SESGA 401_ TAGRQ 406_ EVDNT 411_ FWNGC 416_ GDYYQ 421_ LYDKD 426_ EDSSE 431_ CSDGE 436_ WSASL 441_ PHRFS 446_ GTEKD 451_ QSSSD 456_ ESWET 461_ LPGKD 466_ ENEPE 471_ LQSDS 476_ SGPEE 481_ ENQEL 486_ SLQEG 491_ EQTSL 496_ EEGEI 501_ PWLQY 506_ NEVNE 511_ SSSDE 516_ GNEPA 521_ NEFAQ 526_ PAFML 531_ DGNNN 536_ LEDDS 541_ SVSED 546_ LDVDW 551_ SLFDG 556_ FADGL 561_ GVAEA 566_ ISYVD 571_ PQFLT 576_ YMALE 581_ ERLAQ 586_ AMETA 591_ LAHLE 596_ SLAVD 601_ VEVAN 606_ PPASK 611_ ESIDG 616_ LPETL 621_ VLEDH 626_ TAIGQ 631_ EQCCP 636_ ICCSE 641_ YIKDD 646_ IATEL 651_ PCHHF 656_ FHKPC 661_ VSIWL 666_ QKSGT 671_ CPVCR 676_ RHFPP 681_ AVIEA 686_ SAAPS 691_ SEPDP 696_ DAPPS 701_NDSIA
1: Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390)