Cytochrome P450 26A1 (EC 1.14.13.-) (Cytochrome P450 retinoic acid-inactivating 1) (Cytochrome P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome)
1_MGLPA 6_ LLASA 11_ LCTFV 16_ LPLLL 21_ FLAAI 26_ KLWDL 31_ YCVSG 36_ RDRSC 41_ ALPLP 46_ PGTMG 51_ FPFFG 56_ ETLQM 61_ VLQRR 66_ KFLQM 71_ KRRKY 76_ GFIYK 81_ THLFG 86_ RPTVR 91_ VMGAD 96_ NVRRI 101_ LLGEH 106_ RLVSV 111_ HWPAS 116_ VRTIL 121_ GSGCL 126_ SNLHD 131_ SSHKQ 136_ RKKVI 141_ MRAFS 146_ REALE 151_ CYVPV 156_ ITEEV 161_ GSSLE 166_ QWLSC 171_ GERGL 176_ LVYPE 181_ VKRLM 186_ FRIAM 191_ RILLG 196_ CEPQL 201_ AGDGD 206_ SEQQL 211_ VEAFE 216_ EMTRN 221_ LFSLP 226_ IDVPF 231_ SGLYR 236_ GMKAR 241_ NLIHA 246_ RIEQN 251_ IRAKI 256_ CGLRA 261_ SEAGQ 266_ GCKDA 271_ LQLLI 276_ EHSWE 281_ RGERL 286_ DMQAL 291_ KQSST 296_ ELLFG 301_ GHETT 306_ ASAAT 311_ SLITY 316_ LGLYP 321_ HVLQK 326_ VREEL 331_ KSKGL 336_ LCKSN 341_ QDNKL 346_ DMEIL 351_ EQLKY 356_ IGCVI 361_ KETLR 366_ LNPPV 371_ PGGFR 376_ VALKT 381_ FELNG 386_ YQIPK 391_ GWNVI 396_ YSICD 401_ THDVA 406_ EIFTN 411_ KEEFN 416_ PDRFM 421_ LPHPE 426_ DASRF 431_ SFIPF 436_ GGGLR 441_ SCVGK 446_ EFAKI 451_ LLKIF 456_ TVELA 461_ RHCDW 466_ QLLNG 471_ PPTMK 476_ TSPTV 481_ YPVDN 486_ LPARF 491_THFHG
1: A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (PubMed:22020119, PubMed:9228017, PubMed:9716180). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling (PubMed:22020119, PubMed:9228017, PubMed:9716180). Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (Probable). Involved in the convertion of atRA to all-trans-4-oxo-RA. Able to metabolize other RAs such as 9-cis, 13-cis and 9,13-di-cis RA (By similarity) (PubMed:9228017). Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (PubMed:26937021)