Cone-rod homeobox protein
1_MMAYM 6_ NPGPH 11_ YSVNA 16_ LALSG 21_ PSVDL 26_ MHQAV 31_ PYPSA 36_ PRKQR 41_ RERTT 46_ FTRSQ 51_ LEELE 56_ ALFAK 61_ TQYPD 66_ VYARE 71_ EVALK 76_ INLPE 81_ SRVQV 86_ WFKNR 91_ RAKCR 96_ QQRQQ 101_ QKQQQ 106_ QPPGG 111_ QAKAR 116_ PAKRK 121_ AGTSP 126_ RPSTD 131_ VCPDP 136_ LGISD 141_ SYSPP 146_ LPGPS 151_ GSPTT 156_ AVATV 161_ SIWSP 166_ ASESP 171_ LPEAQ 176_ RAGLV 181_ ASGPS 186_ LTSAP 191_ YAMTY 196_ APASA 201_ FCSSP 206_ SAYGS 211_ PSSYF 216_ SGLDP 221_ YLSPM 226_ VPQLG 231_ GPALS 236_ PLSGP 241_ SVGPS 246_ LAQSP 251_ TSLSG 256_ QSYGA 261_ YSPVD 266_ SLEFK 271_ DPTGT 276_ WKFTY 281_ NPMDP 286_ LDYKD 291_QSAWK
1: Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors