PHD finger protein 1 (Protein PHF1) (hPHF1) (Polycomb-like protein 1) (hPCl1)
1_MAQPP 6_ RLSRS 11_ GASSL 16_ WDPAS 21_ PAPTS 26_ GPRPR 31_ LWEGQ 36_ DVLAR 41_ WTDGL 46_ LYLGT 51_ IKKVD 56_ SAREV 61_ CLVQF 66_ EDDSQ 71_ FLVLW 76_ KDISP 81_ AALPG 86_ EELLC 91_ CVCRS 96_ ETVVP 101_ GNRLV 106_ SCEKC 111_ RHAYH 116_ QDCHV 121_ PRAPA 126_ PGEGE 131_ GTSWV 136_ CRQCV 141_ FAIAT 146_ KRGGA 151_ LKKGP 156_ YARAM 161_ LGMKL 166_ SLPYG 171_ LKGLD 176_ WDAGH 181_ LSNRQ 186_ QSYCY 191_ CGGPG 196_ EWNLK 201_ MLQCR 206_ SCLQW 211_ FHEAC 216_ TQCLS 221_ KPLLY 226_ GDRFY 231_ EFECC 236_ VCRGG 241_ PEKVR 246_ RLQLR 251_ WVDVA 256_ HLVLY 261_ HLSVC 266_ CKKKY 271_ FDFDR 276_ EILPF 281_ TSENW 286_ DSLLL 291_ GELSD 296_ TPKGE 301_ RSSRL 306_ LSALN 311_ SHKDR 316_ FISGR 321_ EIKKR 326_ KCLFG 331_ LHARM 336_ PPPVE 341_ PPTGD 346_ GALTS 351_ FPSGQ 356_ GPGGG 361_ VSRPL 366_ GKRRR 371_ PEPEP 376_ LRRRQ 381_ KGKVE 386_ ELGPP 391_ SAVRN 396_ QPEPQ 401_ EQRER 406_ AHLQR 411_ ALQAS 416_ VSPPS 421_ PSPNQ 426_ SYQGS 431_ SGYNF 436_ RPTDA 441_ RCLPS 446_ SPIRM 451_ FASFH 456_ PSAST 461_ AGTSG 466_ DSGPP 471_ DRSPL 476_ ELHIG 481_ FPTDI 486_ PKSAP 491_ HSMTA 496_ SSSSV 501_ SSPSP 506_ GLPRR 511_ SAPPS 516_ PLCRS 521_ LSPGT 526_ GGGVR 531_ GGVGY 536_ LSRGD 541_ PVRVL 546_ ARRVR 551_ PDGSV 556_ QYLVE 561_WGGGG
1: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464, PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53