Septin-4 (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Peanut-like protein 2)
1_MDRSL 6_ GWQGN 11_ SVPED 16_ RTEAG 21_ IKRFL 26_ EDTTD 31_ DGELS 36_ KFVKD 41_ FSGNA 46_ SCHPP 51_ EAKTW 56_ ASRPQ 61_ VPEPR 66_ PQAPD 71_ LYDDD 76_ LEFRP 81_ PSRPQ 86_ SSDNQ 91_ QYFCA 96_ PAPLS 101_ PSARP 106_ RSPWG 111_ KLDPY 116_ DSSED 121_ DKEYV 126_ GFATL 131_ PNQVH 136_ RKSVK 141_ KGFDF 146_ TLMVA 151_ GESGL 156_ GKSTL 161_ VNSLF 166_ LTDLY 171_ RDRKL 176_ LGAEE 181_ RIMQT 186_ VEITK 191_ HAVDI 196_ EEKGV 201_ RLRLT 206_ IVDTP 211_ GFGDA 216_ VNNTE 221_ CWKPV 226_ AEYID 231_ QQFEQ 236_ YFRDE 241_ SGLNR 246_ KNIQD 251_ NRVHC 256_ CLYFI 261_ SPFGH 266_ GLRPL 271_ DVEFM 276_ KALHQ 281_ RVNIV 286_ PILAK 291_ ADTLT 296_ PPEVD 301_ HKKRK 306_ IREEI 311_ EHFGI 316_ KIYQF 321_ PDCDS 326_ DEDED 331_ FKLQD 336_ QALKE 341_ SIPFA 346_ VIGSN 351_ TVVEA 356_ RGRRV 361_ RGRLY 366_ PWGIV 371_ EVENP 376_ GHCDF 381_ VKLRT 386_ MLVRT 391_ HMQDL 396_ KDVTR 401_ ETHYE 406_ NYRAQ 411_ CIQSM 416_ TRLVV 421_ KERNR 426_ NKLTR 431_ ESGTD 436_ FPIPA 441_ VPPGT 446_ DPETE 451_ KLIRE 456_ KDEEL 461_ RRMQE 466_ MLHKI 471_QKQMK
1: Filament-forming cytoskeletal GTPase (Probable). Pro-apoptotic protein involved in LGR5-positive intestinal stem cell and Paneth cell expansion in the intestines, via its interaction with XIAP (By similarity). May also play a role in the regulation of cell fate in the intestine (By similarity). Positive regulator of apoptosis involved in hematopoietic stem cell homeostasis; via its interaction with XIAP (By similarity). Negative regulator of repair and hair follicle regeneration in response to injury, due to inhibition of hair follicle stem cell proliferation, potentially via its interaction with XIAP (By similarity). Plays an important role in male fertility and sperm motility (By similarity). During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm (By similarity). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Required for dopaminergic metabolism in presynaptic autoreceptors; potentially via activity as a presynaptic scaffold protein (By similarity)
2: Required for the induction of cell death mediated by TGF-beta and possibly by other apoptotic stimuli (PubMed:11146656, PubMed:15837787). Induces apoptosis through binding and inhibition of XIAP resulting in significant reduction in XIAP levels, leading to caspase activation and cell death (PubMed:15029247). Mediates the interaction between BCL2 and XIAP, thereby positively regulating the ubiquitination and degradation of BCL2 and promoting apoptosis (PubMed:29020630)