Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPS synthase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK 1) (SK1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)]
1_MEIPG 6_ SLCKK 11_ VKLSN 16_ NAQNW 21_ GMQRA 26_ TNVTY 31_ QAHHV 36_ SRNKR 41_ GQVVG 46_ TRGGF 51_ RGCTV 56_ WLTGL 61_ SGAGK 66_ TTVSM 71_ ALEEY 76_ LVCHG 81_ IPCYT 86_ LDGDN 91_ IRQGL 96_ NKNLG 101_ FSPED 106_ REENV 111_ RRIAE 116_ VAKLF 121_ ADAGL 126_ VCITS 131_ FISPY 136_ TQDRN 141_ NARQI 146_ HEGAS 151_ LPFFE 156_ VFVDA 161_ PLHVC 166_ EQRDV 171_ KGLYK 176_ KARAG 181_ EIKGF 186_ TGIDS 191_ EYEKP 196_ EAPEL 201_ VLKTD 206_ SCDVN 211_ DCVQQ 216_ VVELL 221_ QERDI 226_ VPVDA 231_ SYEVK 236_ ELYVP 241_ ENKLH 246_ LAKTD 251_ AETLP 256_ ALKIN 261_ KVDMQ 266_ WVQVL 271_ AEGWA 276_ TPLNG 281_ FMRER 286_ EYLQC 291_ LHFDC 296_ LLDGG 301_ VINLS 306_ VPIVL 311_ TATHE 316_ DKERL 321_ DGCTA 326_ FALMY 331_ EGRRV 336_ AILRN 341_ PEFFE 346_ HRKEE 351_ RCARQ 356_ WGTTC 361_ KNHPY 366_ IKMVM 371_ EQGDW 376_ LIGGD 381_ LQVLD 386_ RVYWN 391_ DGLDQ 396_ YRLTP 401_ TELKQ 406_ KFKDM 411_ NADAV 416_ FAFQL 421_ RNPVH 426_ NGHAL 431_ LMQDT 436_ HKQLL 441_ ERGYR 446_ RPVLL 451_ LHPLG 456_ GWTKD 461_ DDVPL 466_ MWRMK 471_ QHAAV 476_ LEEGV 481_ LNPET 486_ TVVAI 491_ FPSPM 496_ MYAGP 501_ TEVQW 506_ HCRAR 511_ MVAGA 516_ NFYIV 521_ GRDPA 526_ GMPHP 531_ ETGKD 536_ LYEPS 541_ HGAKV 546_ LTMAP 551_ GLITL 556_ EIVPF 561_ RVAAY 566_ NKKKK 571_ RMDYY 576_ DSEHH 581_ EDFEF 586_ ISGTR 591_ MRKLA 596_ REGQK 601_ PPEGF 606_ MAPKA 611_ WTVLT 616_EYYKS
1: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:14747722, PubMed:9576487, PubMed:9648242, PubMed:9668121). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487)