Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK)
1_MANFQ 6_ EHLSC 11_ SSSPH 16_ LPFSE 21_ SKTFN 26_ GLQDE 31_ LTAMG 36_ NHPSP 41_ KLLED 46_ QQEKG 51_ MVRTE 56_ LIESV 61_ HSPVT 66_ TTVLT 71_ SVSED 76_ SRDQF 81_ ENSVL 86_ QLREH 91_ DESET 96_ AVSQG 101_ NSNTV 106_ DGEST 111_ SGTED 116_ IKIQF 121_ SRSGS 126_ GSGGF 131_ LEGLF 136_ GCLRP 141_ VWNII 146_ GKAYS 151_ TDYKL 156_ QQQDT 161_ WEVPF 166_ EEISE 171_ LQWLG 176_ SGAQG 181_ AVFLG 186_ KFRAE 191_ EVAIK 196_ KVREQ 201_ NETDI 206_ KHLRK 211_ LKHPN 216_ IIAFK 221_ GVCTQ 226_ APCYC 231_ IIMEY 236_ CAHGQ 241_ LYEVL 246_ RAGRK 251_ ITPRL 256_ LVDWS 261_ TGIAS 266_ GMNYL 271_ HLHKI 276_ IHRDL 281_ KSPNV 286_ LVTHT 291_ DAVKI 296_ SDFGT 301_ SKELS 306_ DKSTK 311_ MSFAG 316_ TVAWM 321_ APEVI 326_ RNEPV 331_ SEKVD 336_ IWSFG 341_ VVLWE 346_ LLTGE 351_ IPYKD 356_ VDSSA 361_ IIWGV 366_ GSNSL 371_ HLPVP 376_ STCPD 381_ GFKIL 386_ MKQTW 391_ QSKPR 396_ NRPSF 401_ RQTLM 406_ HLDIA 411_ SADVL 416_ ATPQE 421_ TYFKS 426_ QAEWR 431_ EEVKK 436_ HFEKI 441_ KSEGT 446_ CIHRL 451_ DEELI 456_ RRRRE 461_ ELRHA 466_ LDIRE 471_ HYERK 476_ LERAN 481_ NLYME 486_ LSAIM 491_ LQLEM 496_ REKEL 501_ IKREQ 506_ AVEKK 511_ YPGTY 516_ KRHPV 521_ RPIIH 526_ PNAME 531_ KLMKR 536_ KGVPH 541_ KSGMQ 546_ TKRPD 551_ LLRSE 556_ GIPTT 561_ EVAPT 566_ ASPLS 571_ GSPKM 576_ STSSS 581_ KSRYR 586_ SKPRH 591_ RRGNS 596_ RGSHS 601_ DFAAI 606_ LKNQP 611_ AQENS 616_ PHPTY 621_ LHQAQ 626_ SQYPS 631_ LHHHN 636_ SLQQQ 641_ YQQPP 646_ PAMSQ 651_ SHHPR 656_ LNMHG 661_ QDIAT 666_ CANNL 671_ RYFGP 676_ AAALR 681_ SPLSN 686_ HAQRQ 691_ LPGSS 696_ PDLIS 701_ TAMAA 706_ DCWRS 711_ SEPDK 716_ GQAGP 721_ WGCCQ 726_ ADAYD 731_ PCLQC 736_ RPEQY 741_ GSLDI 746_ PSAEP 751_ VGRSP 756_ DLSKS 761_ PAHNP 766_ LLENA 771_ QSSEK 776_ TEENE 781_ FSGCR 786_ SESSL 791_ GTSHL 796_ GTPPA 801_ LPRKT 806_ RPLQK 811_ SGDDS 816_ SEEEE 821_ GEVDS 826_ EVEFP 831_ RRQRP 836_ HRCIS 841_ SCQSY 846_ STFSS 851_ ENFSV 856_ SDGEE 861_ GNTSD 866_ HSNSP 871_ DELAD 876_ KLEDR 881_ LAEKL 886_ DDLLS 891_ QTPEI 896_ PIDIS 901_ SHSDG 906_ LSDKE 911_ CAVRR 916_ VKTQM 921_ SLGKL 926_ CVEER 931_ GYENP 936_ MQFEE 941_ SDCDS 946_ SDGEC 951_ SDATV 956_ RTNKH 961_YSSAT
1: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B