Beta-1,4-galactosyltransferase 5 (Beta-1,4-GalTase 5) (Beta4Gal-T5) (b4Gal-T5) (EC 2.4.1.-) (Beta-1,4-GalT II) (Glucosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.274) (Lactosylceramide synthase) (LacCer synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5)
1_MRARR 6_ GLLRL 11_ PRRSL 16_ LAALF 21_ FFSLS 26_ SSLLY 31_ FVYVA 36_ PGIVN 41_ TYLFM 46_ MQAQG 51_ ILIRD 56_ NVRTI 61_ GAQVY 66_ EQVLR 71_ SAYAK 76_ RNSSV 81_ NDSDY 86_ PLDLN 91_ HSETF 96_ LQTTT 101_ FLPED 106_ FTYFA 111_ NHTCP 116_ ERLPS 121_ MKGPI 126_ DINMS 131_ EIGMD 136_ YIHEL 141_ FSKDP 146_ TIKLG 151_ GHWKP 156_ SDCMP 161_ RWKVA 166_ ILIPF 171_ RNRHE 176_ HLPVL 181_ FRHLL 186_ PMLQR 191_ QRLQF 196_ AFYVV 201_ EQVGT 206_ QPFNR 211_ AMLFN 216_ VGFQE 221_ AMKDL 226_ DWDCL 231_ IFHDV 236_ DHIPE 241_ SDRNY 246_ YGCGQ 251_ MPRHF 256_ ATKLD 261_ KYMYL 266_ LPYTE 271_ FFGGV 276_ SGLTV 281_ EQFRK 286_ INGFP 291_ NAFWG 296_ WGGED 301_ DDLWN 306_ RVQNA 311_ GYSVS 316_ RPEGD 321_ TGKYK 326_ SIPHH 331_ HRGEV 336_ QFLGR 341_ YALLR 346_ KSKER 351_ QGLDG 356_ LNNLN 361_ YFANI 366_ TYDAL 371_ YKNIT 376_ VNLTP 381_ELAQV
1: Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:24498430). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (By similarity). Essential for extraembryonic development during early embryogenesis (By similarity)