Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase)
1_MSTFR 6_ QEDVE 11_ DHYEM 16_ GEELG 21_ SGQFA 26_ IVRKC 31_ RQKGT 36_ GKEYA 41_ AKFIK 46_ KRRLS 51_ SSRRG 56_ VSREE 61_ IEREV 66_ NILRE 71_ IRHPN 76_ IITLH 81_ DIFEN 86_ KTDVV 91_ LILEL 96_ VSGGE 101_ LFDFL 106_ AEKES 111_ LTEDE 116_ ATQFL 121_ KQILD 126_ GVHYL 131_ HSKRI 136_ AHFDL 141_ KPENI 146_ MLLDK 151_ NVPNP 156_ RIKLI 161_ DFGIA 166_ HKIEA 171_ GNEFK 176_ NIFGT 181_ PEFVA 186_ PEIVN 191_ YEPLG 196_ LEADM 201_ WSIGV 206_ ITYIL 211_ LSGAS 216_ PFLGE 221_ TKQET 226_ LTNIS 231_ AVNYD 236_ FDEEY 241_ FSNTS 246_ ELAKD 251_ FIRRL 256_ LVKDP 261_ KRRMT 266_ IAQSL 271_ EHSWI 276_ KAIRR 281_ RNVRG 286_ EDSGR 291_ KPERR 296_ RLKTT 301_ RLKEY 306_ TIKSH 311_ SSLPP 316_ NNSYA 321_ DFERF 326_ SKVLE 331_ EAAAA 336_ EEGLR 341_ ELQRS 346_ RRLCH 351_ EDVEA 356_ LAAIY 361_ EEKEA 366_ WYREE 371_ SDSLG 376_ QDLRR 381_ LRQEL 386_ LKTEA 391_ LKRQA 396_ QEEAK 401_ GALLG 406_ TSGLK 411_ RRFSR 416_ LENRY 421_ EALAK 426_ QVASE 431_ MRFVQ 436_ DLVRA 441_ LEQEK 446_LQGVE
1: Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor