Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5)
1_MEDLD 6_ ALLSD 11_ LETTT 16_ SHMPR 21_ SGAPK 26_ ERPAE 31_ PLTPP 36_ PSYGH 41_ QPQTG 46_ SGESS 51_ GASGD 56_ KDHLY 61_ STVCK 66_ PRSPK 71_ PAAPA 76_ APPFS 81_ SSSGV 86_ LGTGL 91_ CELDR 96_ LLQEL 101_ NATQF 106_ NITDE 111_ IMSQF 116_ PSSKV 121_ ASGEQ 126_ KEDQS 131_ EDKKR 136_ PSLPS 141_ SPSPG 146_ LPKAS 151_ ATSAT 156_ LELDR 161_ LMASL 166_ SDFRV 171_ QNHLP 176_ ASGPT 181_ QPPVV 186_ SSTNE 191_ GSPSP 196_ PEPTG 201_ KGSLD 206_ TMLGL 211_ LQSDL 216_ SRRGV 221_ PTQAK 226_ GLCGS 231_ CNKPI 236_ AGQVV 241_ TALGR 246_ AWHPE 251_ HFVCG 256_ GCSTA 261_ LGGSS 266_ FFEKD 271_ GAPFC 276_ PECYF 281_ ERFSP 286_ RCGFC 291_ NQPIR 296_ HKMVT 301_ ALGTH 306_ WHPEH 311_ FCCVS 316_ CGEPF 321_ GDEGF 326_ HEREG 331_ RPYCR 336_ RDFLQ 341_ LFAPR 346_ CQGCQ 351_ GPILD 356_ NYISA 361_ LSALW 366_ HPDCF 371_ VCREC 376_ FAPFS 381_ GGSFF 386_ EHEGR 391_ PLCEN 396_ HFHAR 401_ RGSLC 406_ ATCGL 411_ PVTGR 416_ CVSAL 421_ GRRFH 426_ PDHFT 431_ CTFCL 436_ RPLTK 441_ GSFQE 446_ RAGKP 451_ YCQPC 456_FLKLF
1: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity