CBP80/20-dependent translation initiation factor
1_MENSS 6_ AASAS 11_ SEAGS 16_ SRSQE 21_ IEELE 26_ RFIDS 31_ YVLEY 36_ QVQGL 41_ LADKT 46_ EGDGE 51_ SERTQ 56_ SHISQ 61_ WTADC 66_ SEPLD 71_ SSCSF 76_ SRGRA 81_ PPQQN 86_ GSKDN 91_ SLDML 96_ GTDIW 101_ AANTF 106_ DSFSG 111_ ATWDL 116_ QPEKL 121_ DFTQF 126_ HRKVR 131_ HTPKQ 136_ PLPHI 141_ DREGC 146_ GKGKL 151_ EDGDG 156_ INLND 161_ IEKVL 166_ PAWQG 171_ YHPMP 176_ HEVEI 181_ AHTKK 186_ LFRRR 191_ RNDRR 196_ RQQRP 201_ PGGNK 206_ PQQHG 211_ DHQPG 216_ SAKHN 221_ RDHQK 226_ SYQGG 231_ SAPHP 236_ SGRPT 241_ HHGYS 246_ QNRRW 251_ HHGNM 256_ KHPPG 261_ DKGEA 266_ GAHRN 271_ AKETM 276_ TIENP 281_ KLEDT 286_ AGDTG 291_ HSSLE 296_ APRSP 301_ DTLAP 306_ VASER 311_ LPPQQ 316_ SGGPE 321_ VETKR 326_ KDSIL 331_ PERIG 336_ ERPKI 341_ TLLQS 346_ SKDRL 351_ RRRLK 356_ EKDEV 361_ AVETT 366_ TPQQN 371_ KMDKL 376_ IEILN 381_ SMRNN 386_ SSDVD 391_ TKLTT 396_ FMEEA 401_ QNSTN 406_ SEEML 411_ GEIVR 416_ TIYQK 421_ AVSDR 426_ SFAFT 431_ AAKLC 436_ DKMAL 441_ FMVEG 446_ TKFRS 451_ LLLNM 456_ LQKDF 461_ TVREE 466_ LQQQD 471_ VERWL 476_ GFITF 481_ LCEVF 486_ GTMRS 491_ STGEP 496_ FRVLV 501_ CPIYT 506_ CLREL 511_ LQSQD 516_ VKEDA 521_ VLCCS 526_ MELQS 531_ TGRLL 536_ EEQLP 541_ EMMTE 546_ LLASA 551_ RDKML 556_ CPSES 561_ MLTRS 566_ LLLEV 571_ IELHA 576_ NSWNP 581_ LTPPI 586_ TQYYN 591_RTIQK
1: Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD)