Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2)
1_MSEAP 6_ RFFVG 11_ PEDTE 16_ INPGN 21_ YRHFF 26_ HHADE 31_ DDEEE 36_ DDSPP 41_ ERQIV 46_ VGICS 51_ MAKKS 56_ KSKPM 61_ KEILE 66_ RISLF 71_ KYITV 76_ VVFEE 81_ EVILN 86_ EPVEN 91_ WPLCD 96_ CLISF 101_ HSKGF 106_ PLDKA 111_ VAYAK 116_ LRNPF 121_ VINDL 126_ NMQYL 131_ IQDRR 136_ EVYSI 141_ LQAEG 146_ ILLPR 151_ YAILN 156_ RDPNN 161_ PKECN 166_ LIEGE 171_ DHVEV 176_ NGEVF 181_ QKPFV 186_ EKPVS 191_ AEDHN 196_ VYIYY 201_ PTSAG 206_ GGSQR 211_ LFRKI 216_ GSRSS 221_ VYSPE 226_ SNVRK 231_ TGSYI 236_ YEEFM 241_ PTDGT 246_ DVKVY 251_ TVGPD 256_ YAHAE 261_ ARKSP 266_ ALDGK 271_ VERDS 276_ EGKEV 281_ RYPVI 286_ LNARE 291_ KLIAW 296_ KVCLA 301_ FKQTV 306_ CGFDL 311_ LRANG 316_ QSYVC 321_ DVNGF 326_ SFVKN 331_ SMKYY 336_ DDCAK 341_ ILGNI 346_ VMREL 351_ APQFH 356_ IPWSI 361_ PLEAE 366_ DIPIV 371_ PTTSG 376_ TMMEL 381_ RCVIA 386_ VIRHG 391_ DRTPK 396_ QKMKM 401_ EVRHQ 406_ KFFDL 411_ FEKCD 416_ GYKSG 421_ KLKLK 426_ KPKQL 431_ QEVLD 436_ IARQL 441_ LMELG 446_ QNNDS 451_ EIEEN 456_ KPKLE 461_ QLKTV 466_ LEMYG 471_ HFSGI 476_ NRKVQ 481_ LTYLP 486_ HGCPK 491_ TSSEE 496_ EDSRR 501_ EEPSL 506_ LLVLK 511_ WGGEL 516_ TPAGR 521_ VQAEE 526_ LGRAF 531_ RCMYP 536_ GGQGD 541_ YAGFP 546_ GCGLL 551_ RLHST 556_ YRHDL 561_ KIYAS 566_ DEGRV 571_ QMTAA 576_ AFAKG 581_ LLALE 586_ GELTP 591_ ILVQM 596_ VKSAN 601_ MNGLL 606_ DSDSD 611_ SLSSC 616_ QQRVK 621_ ARLHE 626_ ILQKD 631_ RDFTA 636_ EDYEK 641_ LTPSG 646_ SISLI 651_ KSMHL 656_ IKNPV 661_ KTCDK 666_ VYSLI 671_ QSLTS 676_ QIRHR 681_ MEDPK 686_ SSDIQ 691_ LYHSE 696_ TLELM 701_ LRRWS 706_ KLEKD 711_ FKTKN 716_ GRYDI 721_ SKIPD 726_ IYDCI 731_ KYDVQ 736_ HNGSL 741_ KLENT 746_ MELYR 751_ LSKAL 756_ ADIVI 761_ PQEYG 766_ ITKAE 771_ KLEIA 776_ KGYCT 781_ PLVRK 786_ IRSDL 791_ QRTQD 796_ DDTVN 801_ KLHPV 806_ YSRGV 811_ LSPER 816_ HVRTR 821_ LYFTS 826_ ESHVH 831_ SLLSI 836_ LRYGA 841_ LCNES 846_ KDEQW 851_ KRAMD 856_ YLNVV 861_ NELNY 866_ MTQIV 871_ IMLYE 876_ DPNKD 881_ LSSEE 886_ RFHVE 891_ LHFSP 896_ GAKGC 901_ EEDKN 906_ LPSGY 911_ GYRPA 916_ SRENE 921_ GRRPF 926_ KIDND 931_ DEPHT 936_ SKRDE 941_ VDRAV 946_ ILFKP 951_ MVSEP 956_ IHIHR 961_ KSPLP 966_ RSRKT 971_ ATNDE 976_ ESPLS 981_ VSSPE 986_ GTGTW 991_ LHYTS 996_ GVGTG 1001_ RRRRR 1006_ SGEQI 1011_ TSSPV 1016_ SPKSL 1021_ AFTSS 1026_ IFGSW 1031_ QQVVS 1036_ ENANY 1041_ LRTPR 1046_ TLVEQ 1051_ KQNPT 1056_ VGSHC 1061_ AGLFS 1066_ TSVLG 1071_ GSSSA 1076_ PNLQD 1081_ YARTH 1086_ RKKLT 1091_ SSGCI 1096_ DDATR 1101_ GSAVK 1106_ RFSIS 1111_ FARHP 1116_ TNGFE 1121_ LYSMV 1126_ PSICP 1131_ LETLH 1136_ NALSL 1141_ KQVDE 1146_ FLASI 1151_ ASPSS 1156_ DVPRK 1161_ TAEIS 1166_ STALR 1171_ SSPIM 1176_ RKKVS 1181_ LNTYT 1186_ PAKIL 1191_ PTPPA 1196_ TLKST 1201_ KASSK 1206_ PATSG 1211_ PSSAV 1216_ VPNTS 1221_ SRKKN 1226_ ITSKT 1231_ ETHEH 1236_KKNTG
1: Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114)