Paired box protein Pax-4
1_MHQDG 6_ ISSMN 11_ QLGGL 16_ FVNGR 21_ PLPLD 26_ TRQQI 31_ VRLAV 36_ SGMRP 41_ CDISR 46_ ILKVS 51_ NGCVS 56_ KILGR 61_ YYRTG 66_ VLEPK 71_ GIGGS 76_ KPRLA 81_ TPPVV 86_ ARIAQ 91_ LKGEC 96_ PALFA 101_ WEIQR 106_ QLCAE 111_ GLCTQ 116_ DKTPS 121_ VSSIN 126_ RVLRA 131_ LQEDQ 136_ GLPCT 141_ RLRSP 146_ AVLAP 151_ AVLTP 156_ HSGSE 161_ TPRGT 166_ HPGTG 171_ HRNRT 176_ IFSPS 181_ QAEAL 186_ EKEFQ 191_ RGQYP 196_ DSVAR 201_ GKLAT 206_ ATSLP 211_ EDTVR 216_ VWFSN 221_ RRAKW 226_ RRQEK 231_ LKWEM 236_ QLPGA 241_ SQGLT 246_ VPRVA 251_ PGIIS 256_ AQQSP 261_ GSVPT 266_ AALPA 271_ LEPLG 276_ PSCYQ 281_ LCWAT 286_ APERC 291_ LSDTP 296_ PKACL 301_ KPCWD 306_ CGSFL 311_ LPVIA 316_ PSCVD 321_ VAWPC 326_ LDASL 331_ AHHLI 336_ GGAGK 341_ATPTH
1: Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity