Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
1_MSTAS 6_ AASSS 11_ SSSSA 16_ GEMIE 21_ APSQV 26_ LNFEE 31_ IDYKE 36_ IEVEE 41_ VVGRG 46_ AFGVV 51_ CKAKW 56_ RAKDV 61_ AIKQI 66_ ESESE 71_ RKAFI 76_ VELRQ 81_ LSRVN 86_ HPNIV 91_ KLYGA 96_ CLNPV 101_ CLVME 106_ YAEGG 111_ SLYNV 116_ LHGAE 121_ PLPYY 126_ TAAHA 131_ MSWCL 136_ QCSQG 141_ VAYLH 146_ SMQPK 151_ ALIHR 156_ DLKPP 161_ NLLLV 166_ AGGTV 171_ LKICD 176_ FGTAC 181_ DIQTH 186_ MTNNK 191_ GSAAW 196_ MAPEV 201_ FEGSN 206_ YSEKC 211_ DVFSW 216_ GIILW 221_ EVITR 226_ RKPFD 231_ EIGGP 236_ AFRIM 241_ WAVHN 246_ GTRPP 251_ LIKNL 256_ PKPIE 261_ SLMTR 266_ CWSKD 271_ PSQRP 276_ SMEEI 281_ VKIMT 286_ HLMRY 291_ FPGAD 296_ EPLQY 301_ PCQYS 306_ DEGQS 311_ NSATS 316_ TGSFM 321_ DIAST 326_ NTSNK 331_ SDTNM 336_ EQVPA 341_ TNDTI 346_ KRLES 351_ KLLKN 356_ QAKQQ 361_ SESGR 366_ LSLGA 371_ SRGSS 376_ VESLP 381_ PTSEG 386_ KRMSA 391_ DMSEI 396_ EARIA 401_ ATTAY 406_ SKPKR 411_ GHRKT 416_ ASFGN 421_ ILDVP 426_ EIVIS 431_ GNGQP 436_ RRRSI 441_ QDLTV 446_ TGTEP 451_ GQVSS 456_ RSSSP 461_ SVRMI 466_ TTSGP 471_ TSEKP 476_ TRSHP 481_ WTPDD 486_ STDTN 491_ GSDNS 496_ IPMAY 501_ LTLDH 506_ QLQPL 511_ APCPN 516_ SKESM 521_ AVFEQ 526_ HCKMA 531_ QEYMK 536_ VQTEI 541_ ALLLQ 546_ RKQEL 551_ VAELD 556_ QDEKD 561_ QQNTS 566_ RLVQE 571_ HKKLL 576_ DENKS 581_ LSTYY 586_ QQCKK 591_ QLEVI 596_ RSQQQ 601_KRQGT
1: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Plays an important role in the cascades of cellular responses evoked by changes in the environment (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) (PubMed:16893890, PubMed:9079627). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 (PubMed:11460167, PubMed:8663074). These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) (PubMed:11460167, PubMed:12589052, PubMed:8663074). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex (PubMed:12589052, PubMed:8663074). Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation (PubMed:10094049, PubMed:11460167). In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (PubMed:16893890). Promotes TRIM5 capsid-specific restriction activity (PubMed:21512573). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). Phosphorylates STING1 in response to cGAMP-activation, promoting association between STEEP1 and STING1 and STING1 translocation to COPII vesicles (PubMed:37832545)