Desert hedgehog protein (DHH) (HHG-3) [Cleaved into: Desert hedgehog protein N-product; Desert hedgehog protein C-product]
1_MALLT 6_ NLLPL 11_ CCLAL 16_ LALPA 21_ QSCGP 26_ GRGPV 31_ GRRRY 36_ ARKQL 41_ VPLLY 46_ KQFVP 51_ GVPER 56_ TLGAS 61_ GPAEG 66_ RVARG 71_ SERFR 76_ DLVPN 81_ YNPDI 86_ IFKDE 91_ ENSGA 96_ DRLMT 101_ ERCKE 106_ RVNAL 111_ AIAVM 116_ NMWPG 121_ VRLRV 126_ TEGWD 131_ EDGHH 136_ AQDSL 141_ HYEGR 146_ ALDIT 151_ TSDRD 156_ RNKYG 161_ LLARL 166_ AVEAG 171_ FDWVY 176_ YESRN 181_ HVHVS 186_ VKADN 191_ SLAVR 196_ AGGCF 201_ PGNAT 206_ VRLWS 211_ GERKG 216_ LRELH 221_ RGDWV 226_ LAADA 231_ SGRVV 236_ PTPVL 241_ LFLDR 246_ DLQRR 251_ ASFVA 256_ VETEW 261_ PPRKL 266_ LLTPW 271_ HLVFA 276_ ARGPA 281_ PAPGD 286_ FAPVF 291_ ARRLR 296_ AGDSV 301_ LAPGG 306_ DALRP 311_ ARVAR 316_ VAREE 321_ AVGVF 326_ APLTA 331_ HGTLL 336_ VNDVL 341_ ASCYA 346_ VLESH 351_ QWAHR 356_ AFAPL 361_ RLLHA 366_ LGALL 371_ PGGAV 376_ QPTGM 381_ HWYSR 386_ LLYRL 391_AEELL
1: The C-terminal part of the desert hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (N-product and C-product) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (By similarity). Both activities occur in the endoplasmic reticulum (By similarity). Functions in cell-cell mediated juxtacrine signaling (PubMed:24342078). Promotes endothelium integrity (PubMed:33063110). Binds to PTCH1 receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes in endothelial cells (PubMed:33063110). In Schwann cells, controls the development of the peripheral nerve sheath and the transition of mesenchymal cells to form the epithelium-like structure of the perineurial tube (By similarity)
2: The dually lipidated desert hedgehog protein N-product is essential for a variety of patterning events during development (By similarity). Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (PubMed:11472839, PubMed:33063110). Required for normal testis development and spermatogenesis, namely for the formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules (By similarity). Activates primary cilia signaling on neighboring valve interstitial cells through a paracrine mechanism (By similarity). May induce motor neurons in lateral neural tube and may have a polarizing activity (PubMed:11472839). Prevents the desert hedgehog protein precursor binding to PTCH1 (PubMed:33063110)