ER membrane protein complex subunit 8 (Neighbor of COX4) (Protein FAM158B)
1_MPGVK 6_ LTTQA 11_ YCKMV 16_ LHGAK 21_ YPHCA 26_ VNGLL 31_ VAEKQ 36_ KPRKE 41_ HLPLG 46_ GPGAH 51_ HTLFV 56_ DCIPL 61_ FHGTL 66_ ALAPM 71_ LEVAL 76_ TLIDS 81_ WCKDH 86_ SYVIA 91_ GYYQA 96_ NERVK 101_ DASPN 106_ QVAEK 111_ VASRI 116_ AEGFS 121_ DTALI 126_ MVDNT 131_ KFTMD 136_ CVAPT 141_ IHVYE 146_ HHENR 151_ WRCRD 156_ PHHDY 161_ CEDWP 166_ EAQRI 171_ SASLL 176_ DSRSY 181_ ETLVD 186_ FDNHL 191_ DDIRN 196_ DWTNP 201_EINKA
1: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable)