Glutamate receptor ionotropic, delta-2 (GluD2) (GluR delta-2 subunit)
1_MEVFP 6_ FLLVL 11_ SVWWS 16_ RTWDS 21_ ANADS 26_ IIHIG 31_ AIFDE 36_ SAKKD 41_ DEVFR 46_ TAVGD 51_ LNQNE 56_ EILQT 61_ EKITF 66_ SVTFV 71_ DGNNP 76_ FQAVQ 81_ EACEL 86_ MNQGI 91_ LALVS 96_ SIGCT 101_ SAGSL 106_ QSLAD 111_ AMHIP 116_ HLFIQ 121_ RSTAG 126_ TPRSG 131_ CGLTR 136_ SNRND 141_ DYTLS 146_ VRPPV 151_ YLHDV 156_ ILRVV 161_ TEYAW 166_ QKFII 171_ FYDSE 176_ YDIRG 181_ IQEFL 186_ DKVSQ 191_ QGMDV 196_ ALQKV 201_ ENNIN 206_ KMITT 211_ LFDTM 216_ RIEEL 221_ NRYRD 226_ TLRRA 231_ ILVMN 236_ PATAK 241_ SFITE 246_ VVETN 251_ LVAFD 256_ CHWII 261_ INEEI 266_ NDVDV 271_ QELVR 276_ RSIGR 281_ LTIIR 286_ QTFPV 291_ PQNIS 296_ QRCFR 301_ GNHRI 306_ SSTLC 311_ DPKDP 316_ FAQNM 321_ EISNL 326_ YIYDT 331_ VLLLA 336_ NAFHK 341_ KLEDR 346_ KWHSM 351_ ASLSC 356_ IRKNS 361_ KPWQG 366_ GRSML 371_ ETIKK 376_ GGVSG 381_ LTGEL 386_ EFGEN 391_ GGNPN 396_ VHFEI 401_ LGTNY 406_ GEELG 411_ RGVRK 416_ LGCWN 421_ PVTGL 426_ NGSLT 431_ DKKLE 436_ NNMRG 441_ VVLRV 446_ VTVLE 451_ EPFVM 456_ VSENV 461_ LGKPK 466_ KYQGF 471_ SIDVL 476_ DALSN 481_ YLGFN 486_ YEIYV 491_ APDHK 496_ YGSPQ 501_ EDGTW 506_ NGLVG 511_ ELVFK 516_ RADIG 521_ ISALT 526_ ITPDR 531_ ENVVD 536_ FTTRY 541_ MDYSV 546_ GVLLR 551_ RAEKT 556_ VDMFA 561_ CLAPF 566_ DLSLW 571_ ACIAG 576_ TVLLV 581_ GLLVY 586_ LLNWL 591_ NPPRL 596_ QMGSM 601_ TSTTL 606_ YNSMW 611_ FVYGS 616_ FVQQG 621_ GEVPY 626_ TTLAT 631_ RMMMG 636_ AWWLF 641_ ALIVI 646_ SSYTA 651_ NLAAF 656_ LTITR 661_ IESSI 666_ QSLQD 671_ LSKQT 676_ EIPYG 681_ TVLDS 686_ AVYEH 691_ VRMKG 696_ LNPFE 701_ RDSMY 706_ SQMWR 711_ MINRS 716_ NGSEN 721_ NVLES 726_ QAGIQ 731_ KVKYG 736_ NYAFV 741_ WDAAV 746_ LEYVA 751_ INDPD 756_ CSFYT 761_ IGNTV 766_ ADRGY 771_ GIALQ 776_ HGSPY 781_ RDVFS 786_ QRILE 791_ LQQNG 796_ DMDIL 801_ KHKWW 806_ PKNGQ 811_ CDLYS 816_ SVDTK 821_ QKGGA 826_ LDIKS 831_ FAGVF 836_ CILAA 841_ GIVLS 846_ CFIAM 851_ LETWW 856_ NKRKG 861_ SRVPS 866_ KEDDK 871_ EIDLE 876_ HLHRR 881_ VNSLC 886_ TDDDS 891_ PHKQF 896_ STSSI 901_ DLTPL 906_ DIDTL 911_ PTRQA 916_ LEQIS 921_ DFRNT 926_ HITTT 931_ TFIPE 936_ QIQTL 941_ SRTLS 946_ AKAAS 951_ GFTFG 956_ NVPEH 961_ RTGPF 966_ RHRAP 971_ NGGFF 976_ RSPIK 981_ TMSSI 986_ PYQPT 991_ PTLGL 996_ NLGND 1001_PDRGT
1: Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand (PubMed:34936451). Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the NRX1B-CBLN1-GRID2 triad complex (PubMed:27418511). In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine (PubMed:34936451). However, recent research disputes this ligand-gated cation channel activity (PubMed:39052831). Cation-selective ion channel activity can be triggered by GRM1 in Purkinje cells (PubMed:24357660, PubMed:27276689)