Protein CBFA2T2 (ETO homologous on chromosome 20) (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (p85)
1_MAKES 6_ GISLK 11_ EIQVL 16_ ARQWK 21_ VGPEK 26_ RVPAM 31_ PGSPV 36_ EVKIQ 41_ SRSSP 46_ PTMPP 51_ LPPIN 56_ PGGPR 61_ PVSFT 66_ PTALS 71_ NGINH 76_ SPPTL 81_ NGAPS 86_ PPQRF 91_ SNGPA 96_ SSTSS 101_ ALTNQ 106_ QLPAT 111_ CGARQ 116_ LSKLK 121_ RFLTT 126_ LQQFG 131_ NDISP 136_ EIGEK 141_ VRTLV 146_ LALVN 151_ STVTI 156_ EEFHC 161_ KLQEA 166_ TNFPL 171_ RPFVI 176_ PFLKA 181_ NLPLL 186_ QRELL 191_ HCARA 196_ AKQTP 201_ SQYLA 206_ QHEHL 211_ LLNTS 216_ IASPA 221_ DSSEL 226_ LMEVH 231_ GNGKR 236_ PSPER 241_ REENS 246_ FDRDT 251_ IAPEP 256_ PAKRV 261_ CTISP 266_ APRHS 271_ PALTV 276_ PLMNP 281_ GGQFH 286_ PTPPP 291_ LQHYT 296_ LEDIA 301_ TSHLY 306_ REPNK 311_ MLEHR 316_ EVRDR 321_ HHSLG 326_ LNGGY 331_ QDELV 336_ DHRLT 341_ EREWA 346_ DEWKH 351_ LDHAL 356_ NCIME 361_ MVEKT 366_ RRSMA 371_ VLRRC 376_ QESDR 381_ EELNY 386_ WKRRY 391_ NENTE 396_ LRKTG 401_ TELVS 406_ RQHSP 411_ GSADS 416_ LSNDS 421_ QREFN 426_ SRPGT 431_ GYVPV 436_ EFWKK 441_ TEEAV 446_ NKVKI 451_ QAMSE 456_ VQKAV 461_ AEAEQ 466_ KAFEV 471_ IATER 476_ ARMEQ 481_ TIADV 486_ KRQAA 491_ EDAFL 496_ VINEQ 501_ EESTE 506_ NCWNC 511_ GRKAS 516_ ETCSG 521_ CNIAR 526_ YCGSF 531_ CQHKD 536_ WERHH 541_ RLCGQ 546_ NLHGQ 551_ SPHGQ 556_ GRPLL 561_ PVGRG 566_ SSARS 571_ ADCSV 576_ PSPAL 581_ DKTSA 586_ TTSRS 591_ STPAS 596_VTAID
1: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity)