Membrane-bound transcription factor site-2 protease (EC 3.4.24.85) (Endopeptidase S2P) (Sterol regulatory element-binding proteins intramembrane protease) (SREBPs intramembrane protease)
1_MIPVS 6_ LVVVV 11_ VGGWT 16_ VVYLT 21_ DLVLK 26_ SSVYF 31_ KHSYE 36_ DWLEN 41_ NGLSI 46_ SPFHI 51_ RWQTA 56_ VFNRA 61_ FYSWG 66_ RRKAR 71_ MLYQW 76_ FNFGM 81_ VFGVI 86_ AMFSS 91_ FFLLG 96_ KTLMQ 101_ TLAQM 106_ MADSP 111_ SSYSS 116_ SSSSS 121_ SSSSS 126_ SSSSS 131_ SSSSS 136_ SLHNE 141_ QVLQV 146_ VVPGI 151_ NLPVN 156_ QLTYF 161_ FTAVL 166_ ISGVV 171_ HEIGH 176_ GIAAI 181_ REQVR 186_ FNGFG 191_ IFLFI 196_ IYPGA 201_ FVDLF 206_ TTHLQ 211_ LISPV 216_ QQLRI 221_ FCAGI 226_ WHNFV 231_ LALLG 236_ ILALV 241_ LLPVI 246_ LLPFY 251_ YTGVG 256_ VLITE 261_ VAEDS 266_ PAIGP 271_ RGLFV 276_ GDLVT 281_ HLQDC 286_ PVTNV 291_ QDWNE 296_ CLDTI 301_ AYEPQ 306_ IGYCI 311_ SASTL 316_ QQLSF 321_ PVRAY 326_ KRLDG 331_ STECC 336_ NNHSL 341_ TDVCF 346_ SYRNN 351_ FNKRL 356_ HTCLP 361_ ARKAV 366_ EATQV 371_ CRTNK 376_ DCKKS 381_ SSSSF 386_ CIIPS 391_ LETHT 396_ RLIKV 401_ KHPPQ 406_ IDMLY 411_ VGHPL 416_ HLHYT 421_ VSITS 426_ FIPRF 431_ NFLSI 436_ DLPVV 441_ VETFV 446_ KYLIS 451_ LSGAL 456_ AIVNA 461_ VPCFA 466_ LDGQW 471_ ILNSF 476_ LDATL 481_ TSVIG 486_ DNDVK 491_ DLIGF 496_ FILLG 501_ GSVLL 506_ AANVT 511_LGLWM
1: Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:10805775, PubMed:11163209). Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached (PubMed:10805775, PubMed:27380894, PubMed:9659902). Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription (PubMed:10805775, PubMed:27380894, PubMed:9659902). Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B) (PubMed:11163209). Involved in intramembrane proteolysis during bone formation (PubMed:27380894). In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression (PubMed:16417584)