Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)
1_MAAPR 6_ AGRGA 11_ GWSLR 16_ AWRAL 21_ GGIRW 26_ GRRPR 31_ LTPDL 36_ RALLT 41_ SGTSD 46_ PRARV 51_ TYGTP 56_ SLWAR 61_ LSVGV 66_ TEPRA 71_ CLTSG 76_ TPGPR 81_ AQLTA 86_ VTPDT 91_ RTREA 96_ SENSG 101_ TRSRA 106_ WLAVA 111_ LGAGG 116_ AVLLL 121_ LWGGG 126_ RGPPA 131_ VLAAV 136_ PSPPP 141_ ASPRS 146_ QYNFI 151_ ADVVE 156_ KTAPA 161_ VVYIE 166_ ILDRH 171_ PFLGR 176_ EVPIS 181_ NGSGF 186_ VVAAD 191_ GLIVT 196_ NAHVV 201_ ADRRR 206_ VRVRL 211_ LSGDT 216_ YEAVV 221_ TAVDP 226_ VADIA 231_ TLRIQ 236_ TKEPL 241_ PTLPL 246_ GRSAD 251_ VRQGE 256_ FVVAM 261_ GSPFA 266_ LQNTI 271_ TSGIV 276_ SSAQR 281_ PARDL 286_ GLPQT 291_ NVEYI 296_ QTDAA 301_ IDFGN 306_ SGGPL 311_ VNLDG 316_ EVIGV 321_ NTMKV 326_ TAGIS 331_ FAIPS 336_ DRLRE 341_ FLHRG 346_ EKKNS 351_ SSGIS 356_ GSQRR 361_ YIGVM 366_ MLTLS 371_ PSILA 376_ ELQLR 381_ EPSFP 386_ DVQHG 391_ VLIHK 396_ VILGS 401_ PAHRA 406_ GLRPG 411_ DVILA 416_ IGEQM 421_ VQNAE 426_ DVYEA 431_ VRTQS 436_ QLAVQ 441_ IRRGR 446_ ETLTL 451_YVTPE
1: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein (PubMed:10873535). Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism (PubMed:15200957). Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6 (PubMed:36758104, PubMed:36758105). Cleaves THAP5 and promotes its degradation during apoptosis (PubMed:19502560)
2: Seems to be proteolytically inactive