Krueppel-like factor 4 (Epithelial zinc finger protein EZF) (Gut-enriched krueppel-like factor)
1_MRQPP 6_ GESDM 11_ AVSDA 16_ LLPSF 21_ STFAS 26_ GPAGR 31_ EKTLR 36_ QAGAP 41_ NNRWR 46_ EELSH 51_ MKRLP 56_ PVLPG 61_ RPYDL 66_ AAATV 71_ ATDLE 76_ SGGAG 81_ AACGG 86_ SNLAP 91_ LPRRE 96_ TEEFN 101_ DLLDL 106_ DFILS 111_ NSLTH 116_ PPESV 121_ AATVS 126_ SSASA 131_ SSSSS 136_ PSSSG 141_ PASAP 146_ STCSF 151_ TYPIR 156_ AGNDP 161_ GVAPG 166_ GTGGG 171_ LLYGR 176_ ESAPP 181_ PTAPF 186_ NLADI 191_ NDVSP 196_ SGGFV 201_ AELLR 206_ PELDP 211_ VYIPP 216_ QQPQP 221_ PGGGL 226_ MGKFV 231_ LKASL 236_ SAPGS 241_ EYGSP 246_ SVISV 251_ SKGSP 256_ DGSHP 261_ VVVAP 266_ YNGGP 271_ PRTCP 276_ KIKQE 281_ AVSSC 286_ THLGA 291_ GPPLS 296_ NGHRP 301_ AAHDF 306_ PLGRQ 311_ LPSRT 316_ TPTLG 321_ LEEVL 326_ SSRDC 331_ HPALP 336_ LPPGF 341_ HPHPG 346_ PNYPS 351_ FLPDQ 356_ MQPQV 361_ PPLHY 366_ QGQSR 371_ GFVAR 376_ AGEPC 381_ VCWPH 386_ FGTHG 391_ MMLTP 396_ PSSPL 401_ ELMPP 406_ GSCMP 411_ EEPKP 416_ KRGRR 421_ SWPRK 426_ RTATH 431_ TCDYA 436_ GCGKT 441_ YTKSS 446_ HLKAH 451_ LRTHT 456_ GEKPY 461_ HCDWD 466_ GCGWK 471_ FARSD 476_ ELTRH 481_ YRKHT 486_ GHRPF 491_ QCQKC 496_ DRAFS 501_ RSDHL 506_ALHMK
1: Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription