Aflatoxin B1 aldehyde reductase member 2 (EC 1.1.1.n11) (AFB1 aldehyde reductase 1) (AFB1-AR 1) (Aldoketoreductase 7) (Succinic semialdehyde reductase) (SSA reductase)
1_MLSAA 6_ SRVVS 11_ RAAVH 16_ CALRS 21_ PPPEA 26_ RALAM 31_ SRPPP 36_ PRVAS 41_ VLGTM 46_ EMGRR 51_ MDAPA 56_ SAAAV 61_ RAFLE 66_ RGHTE 71_ LDTAF 76_ MYSDG 81_ QSETI 86_ LGGLG 91_ LGLGG 96_ GDCRV 101_ KIATK 106_ ANPWD 111_ GKSLK 116_ PDSVR 121_ SQLET 126_ SLKRL 131_ QCPQV 136_ DLFYL 141_ HAPDH 146_ GTPVE 151_ ETLHA 156_ CQRLH 161_ QEGKF 166_ VELGL 171_ SNYAS 176_ WEVAE 181_ ICTLC 186_ KSNGW 191_ ILPTV 196_ YQGMY 201_ NATTR 206_ QVETE 211_ LFPCL 216_ RHFGL 221_ RFYAY 226_ NPLAG 231_ GLLTG 236_ KYKYE 241_ DKDGK 246_ QPVGR 251_ FFGNS 256_ WAETY 261_ RNRFW 266_ KEHHF 271_ EAIAL 276_ VEKAL 281_ QAAYG 286_ ASAPS 291_ VTSAA 296_ LRWMY 301_ HHSQL 306_ QGAHG 311_ DAVIL 316_ GMSSL 321_ EQLEQ 326_ NLAAT 331_ EEGPL 336_ EPAVV 341_ DAFNQ 346_ AWHLV 351_AHECP
1: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen