Prominin-1 (Antigen AC133) (Prominin-like protein 1) (CD antigen CD133)
1_MALVL 6_ GSLLL 11_ LGLCG 16_ NSFSG 21_ GQPSS 26_ TDAPK 31_ AWNYE 36_ LPATN 41_ YETQD 46_ SHKAG 51_ PIGIL 56_ FELVH 61_ IFLYV 66_ VQPRD 71_ FPEDT 76_ LRKFL 81_ QKAYE 86_ SKIDY 91_ DKPET 96_ VILGL 101_ KIVYY 106_ EAGII 111_ LCCVL 116_ GLLFI 121_ ILMPL 126_ VGYFF 131_ CMCRC 136_ CNKCG 141_ GEMHQ 146_ RQKEN 151_ GPFLR 156_ KCFAI 161_ SLLVI 166_ CIIIS 171_ IGIFY 176_ GFVAN 181_ HQVRT 186_ RIKRS 191_ RKLAD 196_ SNFKD 201_ LRTLL 206_ NETPE 211_ QIKYI 216_ LAQYN 221_ TTKDK 226_ AFTDL 231_ NSINS 236_ VLGGG 241_ ILDRL 246_ RPNII 251_ PVLDE 256_ IKSMA 261_ TAIKE 266_ TKEAL 271_ ENMNS 276_ TLKSL 281_ HQQST 286_ QLSSS 291_ LTSVK 296_ TSLRS 301_ SLNDP 306_ LCLVH 311_ PSSET 316_ CNSIR 321_ LSLSQ 326_ LNSNP 331_ ELRQL 336_ PPVDA 341_ ELDNV 346_ NNVLR 351_ TDLDG 356_ LVQQG 361_ YQSLN 366_ DIPDR 371_ VQRQT 376_ TTVVA 381_ GIKRV 386_ LNSIG 391_ SDIDN 396_ VTQRL 401_ PIQDI 406_ LSAFS 411_ VYVNN 416_ TESYI 421_ HRNLP 426_ TLEEY 431_ DSYWW 436_ LGGLV 441_ ICSLL 446_ TLIVI 451_ FYYLG 456_ LLCGV 461_ CGYDR 466_ HATPT 471_ TRGCV 476_ SNTGG 481_ VFLMV 486_ GVGLS 491_ FLFCW 496_ ILMII 501_ VVLTF 506_ VFGAN 511_ VEKLI 516_ CEPYT 521_ SKELF 526_ RVLDT 531_ PYLLN 536_ EDWEY 541_ YLSGK 546_ LFNKS 551_ KMKLT 556_ FEQVY 561_ SDCKK 566_ NRGTY 571_ GTLHL 576_ QNSFN 581_ ISEHL 586_ NINEH 591_ TGSIS 596_ SELES 601_ LKVNL 606_ NIFLL 611_ GAAGR 616_ KNLQD 621_ FAACG 626_ IDRMN 631_ YDSYL 636_ AQTGK 641_ SPAGV 646_ NLLSF 651_ AYDLE 656_ AKANS 661_ LPPGN 666_ LRNSL 671_ KRDAQ 676_ TIKTI 681_ HQQRV 686_ LPIEQ 691_ SLSTL 696_ YQSVK 701_ ILQRT 706_ GNGLL 711_ ERVTR 716_ ILASL 721_ DFAQN 726_ FITNN 731_ TSSVI 736_ IEETK 741_ KYGRT 746_ IIGYF 751_ EHYLQ 756_ WIEFS 761_ ISEKV 766_ ASCKP 771_ VATAL 776_ DTAVD 781_ VFLCS 786_ YIIDP 791_ LNLFW 796_ FGIGK 801_ ATVFL 806_ LPALI 811_ FAVKL 816_ AKYYR 821_ RMDSE 826_ DVYDD 831_ VETIP 836_ MKNME 841_ NGNNG 846_ YHKDH 851_ VYGIH 856_NPVMT
1: May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439)