DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2)
1_MRGKT 6_ FRFEM 11_ QRDLV 16_ SFPLS 21_ PAVRV 26_ KLVSA 31_ GFQTA 36_ EELLE 41_ VKPSE 46_ LSKEV 51_ GISKA 56_ EALET 61_ LQIIR 66_ RECLT 71_ NKPRY 76_ AGTSE 81_ SHKKC 86_ TALEL 91_ LEQEH 96_ TQGFI 101_ ITFCS 106_ ALDDI 111_ LGGGV 116_ PLMKT 121_ TEICG 126_ APGVG 131_ KTQLC 136_ MQLAV 141_ DVQIP 146_ ECFGG 151_ VAGEA 156_ VFIDT 161_ EGSFM 166_ VDRVV 171_ DLATA 176_ CIQHL 181_ QLIAE 186_ KHKGE 191_ EHRKA 196_ LEDFT 201_ LDNIL 206_ SHIYY 211_ FRCRD 216_ YTELL 221_ AQVYL 226_ LPDFL 231_ SEHSK 236_ VRLVI 241_ VDGIA 246_ FPFRH 251_ DLDDL 256_ SLRTR 261_ LLNGL 266_ AQQMI 271_ SLANN 276_ HRLAV 281_ ILTNQ 286_ MTTKI 291_ DRNQA 296_ LLVPA 301_ LGESW 306_ GHAAT 311_ IRLIF 316_ HWDRK 321_ QRLAT 326_ LYKSP 331_ SQKEC 336_ TVLFQ 341_ IKPQG 346_ FRDTV 351_ VTSAC 356_ SLQTE 361_ GSLST 366_ RKRSR 371_DPEEE
1: Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD51 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis