Beta-1,4-glucuronyltransferase 1 (EC 2.4.1.-) (I-beta-1,3-N-acetylglucosaminyltransferase) (iGnT) (N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase) (Poly-N-acetyllactosamine extension enzyme) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1)
1_MQMSY 6_ AIRCA 11_ FYQLL 16_ LAALM 21_ LVAML 26_ QLLYL 31_ SLLSG 36_ LHGQE 41_ EQDQY 46_ FEFFP 51_ PSPRS 56_ VDQVK 61_ AQLRT 66_ ALASG 71_ GVLDA 76_ SGDYR 81_ VYRGL 86_ LKTTM 91_ DPNDV 96_ ILATH 101_ ASVDN 106_ LLHLS 111_ GLLER 116_ WEGPL 121_ SVSVF 126_ AATKE 131_ EAQLA 136_ TVLAY 141_ ALSSH 146_ CPDMR 151_ ARVAM 156_ HLVCP 161_ SRYEA 166_ AVPDP 171_ REPGE 176_ FALLR 181_ SCQEV 186_ FDKLA 191_ RVAQP 196_ GINYA 201_ LGTNV 206_ SYPNN 211_ LLRNL 216_ AREGA 221_ NYALV 226_ IDVDM 231_ VPSEG 236_ LWRGL 241_ REMLD 246_ QSNQW 251_ GGTAL 256_ VVPAF 261_ EIRRA 266_ RRMPM 271_ NKNEL 276_ VQLYQ 281_ VGEVR 286_ PFYYG 291_ LCTPC 296_ QAPTN 301_ YSRWV 306_ NLPEE 311_ SLLRP 316_ AYVVP 321_ WQDPW 326_ EPFYV 331_ AGGKV 336_ PTFDE 341_ RFRQY 346_ GFNRI 351_ SQACE 356_ LHVAG 361_ FDFEV 366_ LNEGF 371_ LVHKG 376_ FKEAL 381_ KFHPQ 386_ KEAEN 391_ QHNKI 396_ LYRQF 401_ KQELK 406_AKYPN
1: Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1) (PubMed:19587235, PubMed:23359570, PubMed:25279697, PubMed:25279699). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan (PubMed:25279697, PubMed:25279699). Phosphorylated O-mannosyl glycan is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279697, PubMed:25279699). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1) (By similarity)