Tumor necrosis factor ligand superfamily member 12 (APO3 ligand) (TNF-related weak inducer of apoptosis) (TWEAK) [Cleaved into: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form]
1_MAARR 6_ SQRRR 11_ GRRGE 16_ PGTAL 21_ LVPLA 26_ LGLGL 31_ ALACL 36_ GLLLA 41_ VVSLG 46_ SRASL 51_ SAQEP 56_ AQEEL 61_ VAEED 66_ QDPSE 71_ LNPQT 76_ EESQD 81_ PAPFL 86_ NRLVR 91_ PRRSA 96_ PKGRK 101_ TRARR 106_ AIAAH 111_ YEVHP 116_ RPGQD 121_ GAQAG 126_ VDGTV 131_ SGWEE 136_ ARINS 141_ SSPLR 146_ YNRQI 151_ GEFIV 156_ TRAGL 161_ YYLYC 166_ QVHFD 171_ EGKAV 176_ YLKLD 181_ LLVDG 186_ VLALR 191_ CLEEF 196_ SATAA 201_ SSLGP 206_ QLRLC 211_ QVSGL 216_ LALRP 221_ GSSLR 226_ IRTLP 231_ WAHLK 236_ AAPFL 241_TYFGL
1: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion