Phospholipid-transporting ATPase IC (EC 7.6.2.1) (ATPase class I type 8B member 1) (Familial intrahepatic cholestasis type 1) (P4-ATPase flippase complex alpha subunit ATP8B1)
1_MSTER 6_ DSETT 11_ FDEDS 16_ QPNDE 21_ VVPYS 26_ DDETE 31_ DELDD 36_ QGSAV 41_ EPEQN 46_ RVNRE 51_ AEENR 56_ EPFRK 61_ ECTWQ 66_ VKAND 71_ RKYHE 76_ QPHFM 81_ NTKFL 86_ CIKES 91_ KYANN 96_ AIKTY 101_ KYNAF 106_ TFIPM 111_ NLFEQ 116_ FKRAA 121_ NLYFL 126_ ALLIL 131_ QAVPQ 136_ ISTLA 141_ WYTTL 146_ VPLLV 151_ VLGVT 156_ AIKDL 161_ VDDVA 166_ RHKMD 171_ KEINN 176_ RTCEV 181_ IKDGR 186_ FKVAK 191_ WKEIQ 196_ VGDVI 201_ RLKKN 206_ DFVPA 211_ DILLL 216_ SSSEP 221_ NSLCY 226_ VETAE 231_ LDGET 236_ NLKFK 241_ MSLEI 246_ TDQYL 251_ QREDT 256_ LATFD 261_ GFIEC 266_ EEPNN 271_ RLDKF 276_ TGTLF 281_ WRNTS 286_ FPLDA 291_ DKILL 296_ RGCVI 301_ RNTDF 306_ CHGLV 311_ IFAGA 316_ DTKIM 321_ KNSGK 326_ TRFKR 331_ TKIDY 336_ LMNYM 341_ VYTIF 346_ VVLIL 351_ LSAGL 356_ AIGHA 361_ YWEAQ 366_ VGNSS 371_ WYLYD 376_ GEDDT 381_ PSYRG 386_ FLIFW 391_ GYIIV 396_ LNTMV 401_ PISLY 406_ VSVEV 411_ IRLGQ 416_ SHFIN 421_ WDLQM 426_ YYAEK 431_ DTPAK 436_ ARTTT 441_ LNEQL 446_ GQIHY 451_ IFSDK 456_ TGTLT 461_ QNIMT 466_ FKKCC 471_ INGQI 476_ YGDHR 481_ DASQH 486_ NHNKI 491_ EQVDF 496_ SWNTY 501_ ADGKL 506_ AFYDH 511_ YLIEQ 516_ IQSGK 521_ EPEVR 526_ QFFFL 531_ LAVCH 536_ TVMVD 541_ RTDGQ 546_ LNYQA 551_ ASPDE 556_ GALVN 561_ AARNF 566_ GFAFL 571_ ARTQN 576_ TITIS 581_ ELGTE 586_ RTYNV 591_ LAILD 596_ FNSDR 601_ KRMSI 606_ IVRTP 611_ EGNIK 616_ LYCKG 621_ ADTVI 626_ YERLH 631_ RMNPT 636_ KQETQ 641_ DALDI 646_ FANET 651_ LRTLC 656_ LCYKE 661_ IEEKE 666_ FTEWN 671_ KKFMA 676_ ASVAS 681_ TNRDE 686_ ALDKV 691_ YEEIE 696_ KDLIL 701_ LGATA 706_ IEDKL 711_ QDGVP 716_ ETISK 721_ LAKAD 726_ IKIWV 731_ LTGDK 736_ KETAE 741_ NIGFA 746_ CELLT 751_ EDTTI 756_ CYGED 761_ INSLL 766_ HARME 771_ NQRNR 776_ GGVYA 781_ KFAPP 786_ VQESF 791_ FPPGG 796_ NRALI 801_ ITGSW 806_ LNEIL 811_ LEKKT 816_ KRNKI 821_ LKLKF 826_ PRTEE 831_ ERRMR 836_ TQSKR 841_ RLEAK 846_ KEQRQ 851_ KNFVD 856_ LACEC 861_ SAVIC 866_ CRVTP 871_ KQKAM 876_ VVDLV 881_ KRYKK 886_ AITLA 891_ IGDGA 896_ NDVNM 901_ IKTAH 906_ IGVGI 911_ SGQEG 916_ MQAVM 921_ SSDYS 926_ FAQFR 931_ YLQRL 936_ LLVHG 941_ RWSYI 946_ RMCKF 951_ LRYFF 956_ YKNFA 961_ FTLVH 966_ FWYSF 971_ FNGYS 976_ AQTAY 981_ EDWFI 986_ TLYNV 991_ LYTSL 996_ PVLLM 1001_ GLLDQ 1006_ DVSDK 1011_ LSLRF 1016_ PGLYI 1021_ VGQRD 1026_ LLFNY 1031_ KRFFV 1036_ SLLHG 1041_ VLTSM 1046_ ILFFI 1051_ PLGAY 1056_ LQTVG 1061_ QDGEA 1066_ PSDYQ 1071_ SFAVT 1076_ IASAL 1081_ VITVN 1086_ FQIGL 1091_ DTSYW 1096_ TFVNA 1101_ FSIFG 1106_ SIALY 1111_ FGIMF 1116_ DFHSA 1121_ GIHVL 1126_ FPSAF 1131_ QFTGT 1136_ ASNAL 1141_ RQPYI 1146_ WLTII 1151_ LAVAV 1156_ CLLPV 1161_ VAIRF 1166_ LSMTI 1171_ WPSES 1176_ DKIQK 1181_ HRKRL 1186_ KAEEQ 1191_ WQRRQ 1196_ QVFRR 1201_ GVSTR 1206_ RSAYA 1211_ FSHQR 1216_ GYADL 1221_ ISSGR 1226_ SIRKK 1231_ RSPLD 1236_ AIVAD 1241_ GTAEY 1246_RRTGD
1: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane (PubMed:17948906, PubMed:25315773). May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane (By similarity). Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts (By similarity). Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity (PubMed:20512993). Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2 (PubMed:25239307, PubMed:27301931). Enables CDC42 clustering at the apical membrane during enterocyte polarization through the interaction between CDC42 polybasic region and negatively charged membrane lipids provided by ATP8B1 (By similarity). Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine (PubMed:20510206). Required for the preservation of cochlear hair cells in the inner ear (By similarity). May act as cardiolipin transporter during inflammatory injury (By similarity)